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Immunotherapies in 2023

The rise of precision cellular therapies

  • Year in Review
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From Nature Reviews Rheumatology

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Advances in gene, protein and cellular engineering provide unprecedented opportunities to redirect immune cells to treat autoimmunity. In 2023, novel cellular and precision immunotherapies showed remarkable promise in the treatment of rheumatic diseases.

Key advances

  • B cell-targeted CAR T cell therapies can achieve prolonged clinical remission in various autoimmune diseases2,5.

  • Precision cellular therapies hold promise for selective, antigen-specific elimination of autoreactive B cells6.

  • TCR β-chain variable (TRBV)-targeted antibodies also show potential in T cell-mediated rheumatic diseases10.

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Fig. 1: Emerging immunotherapies for autoimmune and rheumatic diseases.

References

  1. Mueller, F. et al. CD19-targeted CAR-T cells in refractory systemic autoimmune diseases: a monocentric experience from the first fifteen patients. Blood 142, 220–220 (2023).

    Article  Google Scholar 

  2. Qin, C. et al. Anti-BCMA CAR T-cell therapy CT103A in relapsed or refractory AQP4-IgG seropositive neuromyelitis optica spectrum disorders: phase 1 trial interim results. Signal Transduct. Target. Ther. 8, 5 (2023).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Oh, S. et al. Precision targeting of autoantigen-specific B cells in muscle-specific tyrosine kinase myasthenia gravis with chimeric autoantibody receptor T cells. Nat. Biotechnol. 41, 1229–1238 (2023).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Britanova, O. V. et al. Targeted depletion of TRBV9+ T cells as immunotherapy in a patient with ankylosing spondylitis. Nat. Med. 29, 2731–2736 (2023).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Pecher, A.-C. et al. CD19-targeting CAR T cells for myositis and interstitial lung disease associated with antisynthetase syndrome. J. Am. Med. Assoc. 329, 2154–2162 (2023).

    Article  CAS  Google Scholar 

  6. Cortés Hernández, J. et al. An open-label, multicenter, phase 1/2 study to assess safety, efficacy and cellular kinetics of YTB323, a rapid manufacturing CAR-T cell therapy targeting CD19 on B cells, for severe refractory systemic lupus erythematosus: preliminary results [abstract]. Arthritis Rheumatol. 75, suppl 9 (2023).

  7. Feng, J., Hu, Y., Chang, A. H. & Huang, H. CD19/BCMA CAR-T cell therapy for refractory systemic lupus erythematosus - safety and preliminary efficacy data from a phase i clinical study. Blood 142, 4835–4835 (2023).

    Article  Google Scholar 

  8. Yuan, Y. et al. Novel BCMA-CD19 compound CAR-T (cCAR) targets B cells and plasma cells achieving immune reset and eliminates all autoantibodies in systemic lupus erythematosus (SLE) and lupus nephritis (LN) patients resulting in long-term, medication-free remission [abstract]. Arthritis Rheumatol. 75, suppl 9 (2023).

  9. Mog, B. et al. Chimeric autoantigen-T cell receptor (CATCR)-T cell therapies to selectively target autoreactive B cells [abstract]. Arthritis Rheumatol. 74, suppl 9 (2022).

  10. Paul, S. et al. TCR β chain–directed bispecific antibodies for the treatment of T cell cancers. Sci. Transl. Med. 13, eabd3595 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Author information

Authors and Affiliations

  1. Division of Rheumatology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA

    Maximilian F. Konig

  2. Ludwig Center for Cancer Genetics and Therapeutics, Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD, USA

    Maximilian F. Konig

Authors
  1. Maximilian F. Konig
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Correspondence to Maximilian F. Konig.

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Competing interests

M.F.K. is a consultant to Argenx, Atara Biotherapeutics, Revel Pharmaceuticals, Sana Biotechnology and Sanofi. M.F.K. declares that he and The Johns Hopkins University have filed patent applications related to chimeric autoantigen-T cell receptor-T cell therapies and TCR region-targeting approaches.

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Konig, M.F. The rise of precision cellular therapies. Nat Rev Rheumatol 20, 69–70 (2024). https://doi.org/10.1038/s41584-023-01073-6

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  • DOI: https://doi.org/10.1038/s41584-023-01073-6

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