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YAP/TAZ phase separation for transcription

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YAP and TAZ, paralogous mammalian genes, act as the key transcriptional effectors of the Hippo pathway. Two recent reports show that both YAP and TAZ form liquid–liquid phase-separated bodies that promote gene transcription by engaging in super-enhancers.

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Fig. 1: Depiction of the findings from Cai et al.3 and Lu et al.4.

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Authors and Affiliations

  1. Department of Pharmacology and Moores Cancer Center, University of California, San Diego, La Jolla, CA, USA

    J. Matthew Franklin & Kun-Liang Guan

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  1. J. Matthew Franklin
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  2. Kun-Liang Guan
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Correspondence to Kun-Liang Guan.

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Competing interests

K.L.G. is a cofounder of and has equity interest in Vivace Therapeutics.

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Franklin, J.M., Guan, KL. YAP/TAZ phase separation for transcription. Nat Cell Biol 22, 357–358 (2020). https://doi.org/10.1038/s41556-020-0498-8

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