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Biosensing: CRISPR-powered diagnostics

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A CRISPR-associated nuclease that can promiscuously cleave RNAs enables a rapid and cheap test for the single-molecule detection and single-base discrimination of nucleic acids.

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Figure 1: CRISPR-based nucleic acid detection4.

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Authors and Affiliations

  1. Division of Physical Biology, and Bioimaging Center, Shanghai Synchrotron Radiation Facility, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, 201800, China

    Xiaolei Zuo & Hong-Yuan Chen

  2. State Key Laboratory of Analytical Chemistry for Life Sciences, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210093, China

    Chunhai Fan

Authors
  1. Xiaolei Zuo
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  2. Chunhai Fan
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  3. Hong-Yuan Chen
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Corresponding authors

Correspondence to Chunhai Fan or Hong-Yuan Chen.

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Zuo, X., Fan, C. & Chen, HY. Biosensing: CRISPR-powered diagnostics. Nat Biomed Eng 1, 0091 (2017). https://doi.org/10.1038/s41551-017-0091

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