Abstract
Assisted by OSMAC strategy, one new p-terphenyl and two new α‑pyrone derivates, namely nocarterphenyl I (1) and nocardiopyrone D–E (2–3), were obtained and characterized from the marine sediment-derived actinomycete Nocardiopsis sp. HDN154086. The structures of these compounds were determined on the basis of MS, NMR spectroscopic data and single-crystal X-ray diffraction. Compound 1 with a rare 2,2’-bithiazole structure among natural products showed promising activity against five bacteria with MIC values ranging from 0.8 to 1.6 μM and 3 exhibited notable antibacterial activity against MRSA compared the positive control ciprofloxacin.
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Funding
This work was supported by the National Key Research and Development Program of China (2022YFC2804400), the Fundamental Research Funds for the Central Universities (202172002), the Shandong Provincial Natural Science Foundation (ZR2021MH257), the National Natural Science Foundation of China (41976105), and the NSFC-Shandong Joint Fund (U1906212).
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41429_2023_698_MOESM1_ESM.doc
Antibacterial p-Terphenyl and α‑Pyrone Derivates Isolated from the Marine-Derived Actinomycete Nocardiopsis sp. HDN154086
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Zhou, L., Chang, Y., Yang, S. et al. Antibacterial p-terphenyl and α‑pyrone derivates isolated from the marine-derived actinomycete Nocardiopsis sp. HDN154086. J Antibiot 77, 201–205 (2024). https://doi.org/10.1038/s41429-023-00698-9
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DOI: https://doi.org/10.1038/s41429-023-00698-9
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