Abstract
One new angucyclinone derivative, Kanglemycin N (1), and two new biogenetically related α-Pyrones, nocapyrones U-V (2–3), were isolated from a desert-derived Actinomycete Nocardiopsis dassonvillei HDN 154151. Their structures, including absolute configurations, were elucidated by extensive NMR, MS, and ECD analyses. Compound 1 exhibited potent antibacterial activity against Bacillus subtilis, Proteus sp., Vibrio Parahaemolyticus, Escherichia coli and Methicillin-resistant Staphylococcus aureus (MRSA) with MIC values ranging from 0.39 μM to 1.56 μM, and notably the effect of 1 against MRSA significantly exceeded the positive control ciprofloxacin. In addition, compound 1 also showed moderate cytotoxic activity against H69AR, MDA-MB-231, ASPC-1 and K562 cell lines, with IC50 values of 10.46, 8.78, 9.28 and 8.61 μM, respectively.
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Acknowledgements
This work was supported by National Natural Science Foundation of China (41976105, 81991522, 81973234, U1906212), the Fundamental Research Funds for the Central Universities (201941001, 202042005), the Marine S&T Fund of Shandong Province for Pilot National Laboratory for Marine Science and Technology (Qingdao) (2018SDKJ0401-2) and Taishan Scholar Youth Expert Program in Shandong Province (tsqn201812021, 202103153), Shandong Provincial Natural Science Foundation (ZR20119ZD18, 2019KJM004).
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Tang, Z., Chang, Y., Zhu, T. et al. Antibacterial angucyclinone and α-pyrone derivatives from desert-derived Nocardiopsis dassonvillei HDN 154151. J Antibiot 75, 380–384 (2022). https://doi.org/10.1038/s41429-022-00526-6
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DOI: https://doi.org/10.1038/s41429-022-00526-6
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