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Trigger factor finds new jobs and contacts

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Trigger factor is a ribosome-associated chaperone that assists early folding steps of nascent proteins in bacteria. A new study presents the first crystal structure of Trigger factor in complex with a folded protein bound as substrate, challenges the current model for how Trigger factor interacts with substrates and suggests an unexpected role for Trigger factor in protein assembly and ribosome biogenesis.

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Figure 1: Proposed functions of Trigger factor.
Figure 2: Substrate interaction characteristics of Trigger factor.

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Acknowledgements

We thank E. Martinez-Hackert for providing the structures presented in Figure 2a,b, Y. Cully for help in preparation of Figure 1 and D. Huber and G. Kramer for critical reading of this manuscript.

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Authors and Affiliations

  1. Anja Hoffmann and Bernd Bukau are at Zentrum für Molekulare Biologie der Universität Heidelberg (ZMBH), DKFZ-ZMBH Allianz, Heidelberg, Germany.,

    Anja Hoffmann & Bernd Bukau

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  1. Anja Hoffmann
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  2. Bernd Bukau
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Correspondence to Bernd Bukau.

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Hoffmann, A., Bukau, B. Trigger factor finds new jobs and contacts. Nat Struct Mol Biol 16, 1006–1008 (2009). https://doi.org/10.1038/nsmb1009-1006

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