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Axonemal dyneins winch the cilium

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In this issue, Ishikawa and colleagues provide direct evidence to support the 'winch' hypothesis for the dynein motor mechanism, in which the AAA domain motor unit is displaced parallel to the doublet microtubule long axis rather than undergoing a rotary motion.

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Figure 1: Axonemal dynein.
Figure 2: Volume rendering of tomograms of axonemes in the apo and ADP.Vi forms presented by Movassagh et al.1.

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Acknowledgements

The King laboratory is supported by grant GM51293 from the US National Institutes of Health.

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  1. Stephen M. King is in the Department of Molecular, Microbial and Structural Biology, University of Connecticut Health Center, Farmington, Connecticut, USA.,

    Stephen M King

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  1. Stephen M King
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King, S. Axonemal dyneins winch the cilium. Nat Struct Mol Biol 17, 673–674 (2010). https://doi.org/10.1038/nsmb0610-673

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