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Dynactin revealed

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Dynactin is an essential cofactor for the microtubule-based motor cytoplasmic dynein. Two recent papers report structures obtained by cryo-EM of dynactin, the dynein–dynactin complex and dynein–dynactin bound to its track, the microtubule.

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Figure 1: Structures of dynactin and dynein–dynactin–BICD2 bound to a microtubule.

References

  1. Schroer, T.A. Annu. Rev. Cell Dev. Biol. 20, 759–779 (2004).

    Article  CAS  Google Scholar 

  2. Maday, S., Twelvetrees, A.E., Moughamian, A.J. & Holzbaur, E.L. Neuron 84, 292–309 (2014).

    Article  CAS  Google Scholar 

  3. Splinter, D. et al. Mol. Biol. Cell 23, 4226–4241 (2012).

    Article  CAS  Google Scholar 

  4. McKenney, R.J., Huynh, W., Tanenbaum, M.E., Bhabha, G. & Vale, R.D. Science 345, 337–341 (2014).

    Article  CAS  Google Scholar 

  5. Schlager, M.A., Hoang, H.T., Urnavicius, L., Bullock, S.L. & Carter, A.P. EMBO J. 33, 1855–1868 (2014).

    Article  CAS  Google Scholar 

  6. Lipka, J., Kuijpers, M., Jaworski, J. & Hoogenraad, C.C. Biochem. Soc. Trans. 41, 1605–1612 (2013).

    Article  CAS  Google Scholar 

  7. Chowdhury, S., Ketcham, S.A., Schroer, T.A. & Lander, G.C. Nat. Struct. Mol. Biol. 22, 345–347 (2015).

    Article  CAS  Google Scholar 

  8. Urnavicius, L. et al. Science 347, 1441–1446 (2015).

    Article  CAS  Google Scholar 

  9. Schroer, T.A. & Sheetz, M.P. J. Cell Biol. 115, 1309–1318 (1991).

    Article  CAS  Google Scholar 

  10. Gill, S.R. et al. J. Cell Biol. 115, 1639–1650 (1991).

    Article  CAS  Google Scholar 

  11. Imai, H., Narita, A., Maeda, Y. & Schroer, T.A. J. Mol. Biol. 426, 3262–3271 (2014).

    Article  CAS  Google Scholar 

  12. Imai, H., Narita, A., Schroer, T.A. & Maeda, Y. J. Mol. Biol. 359, 833–839 (2006).

    Article  CAS  Google Scholar 

  13. Eckley, D.M. et al. J. Cell Biol. 147, 307–320 (1999).

    Article  CAS  Google Scholar 

  14. Schafer, D.A., Gill, S.R., Cooper, J.A., Heuser, J.E. & Schroer, T.A. J. Cell Biol. 126, 403–412 (1994).

    Article  CAS  Google Scholar 

  15. Waterman-Storer, C.M., Karki, S. & Holzbaur, E.L. Proc. Natl. Acad. Sci. USA 92, 1634–1638 (1995).

    Article  CAS  Google Scholar 

  16. Kühlbrandt, W. eLife 3, e03678 (2014).

    Article  Google Scholar 

  17. Torisawa, T. et al. Nat. Cell Biol. 16, 1118–1124 (2014).

    Article  CAS  Google Scholar 

  18. Trokter, M., Mucke, N. & Surrey, T. Proc. Natl. Acad. Sci. USA 109, 20895–20900 (2012).

    Article  CAS  Google Scholar 

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Acknowledgements

I thank Andres Leschziner (Harvard University) for help in generating Figure 1 and for comments on the text.

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Authors and Affiliations

  1. Samara L. Reck-Peterson is at the Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA.,

    Samara L Reck-Peterson

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  1. Samara L Reck-Peterson
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Correspondence to Samara L Reck-Peterson.

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Reck-Peterson, S. Dynactin revealed. Nat Struct Mol Biol 22, 359–360 (2015). https://doi.org/10.1038/nsmb.3022

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