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New functions for DNA modifications by TET-JBP

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TET and JBP proteins catalyze the oxidation of methylated C bases in the mammalian genome and of the methyl group of T bases in kinetoplastid genomes, respectively. A recent study in Nature Structural & Molecular Biology suggests a new function of 5-methylcytosine oxidation in regulating RNA polymerase II elongation rate that is reminiscent of that of base J in transcription termination in Leishmania.

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Figure 1
Figure 2: The experimental setup used by Kellinger et al.8
Figure 3: Possible functions of 5fC and 5caC in transcription regulation.

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Authors and Affiliations

  1. and the Department of Pharmacology, Yun Huang and Anjana Rao are at the La Jolla Institute for Allergy and Immunology, La Jolla, California. Anjana Rao is also at the Sanford Consortium for Regenerative Medicine, La Jolla, California, University of California, San Diego, San Diego, California.,

    Yun Huang & Anjana Rao

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  1. Yun Huang
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  2. Anjana Rao
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Correspondence to Anjana Rao.

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Huang, Y., Rao, A. New functions for DNA modifications by TET-JBP. Nat Struct Mol Biol 19, 1061–1064 (2012). https://doi.org/10.1038/nsmb.2437

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