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The structure of calcyclin reveals a novel homodimeric fold for S100 Ca2+-binding proteins

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A Corrigendum to this article was published on 01 October 1995

Abstract

The S100 calcium-binding proteins are implicated as effectors in calcium-mediated signal transduction pathways. The three-dimensional structure of the S100 protein calcyclin has been determined in solution in the apo state by NMR spectroscopy and a computational strategy that incorporates a systematic docking protocol. This structure reveals a symmetric homodimeric fold that is unique among calcium-binding proteins. Dimerization is mediated by hydrophobic contacts from several highly conserved residues, which suggests that the dimer fold identified for calcyclin will serve as a structural paradigm for the S100 subfamily of calcium-binding proteins.

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Author notes

  1. Mikael Akke

    Present address: Department of Biochemistry & Molecular Biophysics, Columbia University, New York, New York, 10032, USA

Authors and Affiliations

  1. Department of Molecular Biology, The Scripps Research Institute, 10666 North Torrey Pines Road, La Jolla, California, 92037, USA

    Barbara C. M. Potts, Jarrod Smith, Mikael Akke, Thomas J. Macke, David A. Case & Walter J. Chazin

  2. Department of Pharmacology, Nagoya University Medical School, Japan

    Katsuo Okazaki & Hiroyoshi Hidaka

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  1. Barbara C. M. Potts
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Potts, B., Smith, J., Akke, M. et al. The structure of calcyclin reveals a novel homodimeric fold for S100 Ca2+-binding proteins. Nat Struct Mol Biol 2, 790–796 (1995). https://doi.org/10.1038/nsb0995-790

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