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How calpain is activated by calcium

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The discovery of two unexpected Ca2+-binding sites in the structure of a minimal catalytic domain of μ-calpain reveals a new mechanism underlying the Ca2+-dependent activation of calpains.

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Figure 1: Schematic diagram of human m-calpain.
Figure 2: Ribbon drawings of the protease domain (dII) of calpain in a, the absence6 and b, the presence4 of calcium.

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Authors and Affiliations

  1. the Division of Molecular and Structural Biology, and the Department of Medical Biophysics, Ontario Cancer Institute, University of Toronto, 610 University Avenue, Toronto, M5G 2M9, Ontario, Canada

    Ahmad Khorchid & Mitsuhiko Ikura

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  1. Ahmad Khorchid
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  2. Mitsuhiko Ikura
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Correspondence to Mitsuhiko Ikura.

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Khorchid, A., Ikura, M. How calpain is activated by calcium. Nat Struct Mol Biol 9, 239–241 (2002). https://doi.org/10.1038/nsb0402-239

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