Abstract
Contraction and relaxation of the detrusor smooth muscle (DSM), which makes up the wall of the urinary bladder, facilitates the storage and voiding of urine. Several families of K+ channels, including voltage-gated K+ (KV) channels, Ca2+-activated K+ (KCa) channels, inward-rectifying ATP-sensitive K+ (Kir, KATP) channels, and two-pore-domain K+ (K2P) channels, are expressed and functional in DSM. They control DSM excitability and contractility by maintaining the resting membrane potential and shaping the action potentials that determine the phasic nature of contractility in this tissue. Defects in DSM K+ channel proteins or in the molecules involved in their regulatory pathways may underlie certain forms of bladder dysfunction, such as overactive bladder. K+ channels represent an opportunity for novel pharmacological manipulation and therapeutic intervention in human DSM. Modulation of DSM K+ channels directly or indirectly by targeting their regulatory mechanisms has the potential to control urinary bladder function. This Review summarizes our current state of knowledge of the functional role of K+ channels in DSM in health and disease, with special emphasis on current advancements in the field.
Key Points
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K+ channels control the excitability and contractility of detrusor smooth muscle (DSM)
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Large-conductance voltage-activated and Ca2+-activated (BK) channels, small-conductance Ca2+-activated K+ (SK) channels, two-pore-domain K+ (K2P) channels and voltage-gated K+ (KV) channels are important regulators of DSM function
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BK channelopathy is implicated in some forms of detrusor overactivity and related overactive bladder
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BK, SK, K2P and KV channels represent novel targets for pharmacological or gene-therapy-mediated control of DSM function
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The KV channel family is the most diverse; therefore, it is likely that many new DSM KV channels, some of them bladder-specific, are yet to be discovered
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References
Andersson, K. E. & Arner, A. Urinary bladder contraction and relaxation: physiology and pathophysiology. Physiol. Rev. 84, 935–986 (2004).
Brading, A. F. Spontaneous activity of lower urinary tract smooth muscles: correlation between ion channels and tissue function. J. Physiol. 570, 13–22 (2006).
Christ, G. J. & Hodges, S. Molecular mechanisms of detrusor and corporal myocyte contraction: identifying targets for pharmacotherapy of bladder and erectile dysfunction. Br. J. Pharmacol. 147 (Suppl. 2), S41–S55 (2006).
Gopalakrishnan, M. & Shieh, C. C. Potassium channel subtypes as molecular targets for overactive bladder and other urological disorders. Expert Opin. Ther. Targets 8, 437–458 (2004).
Hashitani, H., Brading, A. F. & Suzuki, H. Correlation between spontaneous electrical, calcium and mechanical activity in detrusor smooth muscle of the guinea-pig bladder. Br. J. Pharmacol. 141, 183–193 (2004).
McCloskey, K. D. Characterization of outward currents in interstitial cells from the guinea pig bladder. J. Urol. 173, 296–301 (2005).
McCloskey, K. D. Interstitial cells in the urinary bladder—localization and function. Neurourol. Urodyn. 29, 82–87 (2010).
McCloskey, K. D., Anderson, U. A. & Carson, C. KCNQ currents and their contribution to resting membrane potential and the excitability of interstitial cells of cajal from the guinea pig bladder. J. Urol. 182, 330–336 (2009).
Ashcroft, F. M. From molecule to malady. Nature 440, 440–447 (2006).
Petkov, G. V. in Pharmacology: Principles and Practice (eds Hacker, M., Messer, W. S. & Bachmann, K. A.) 387–427 (Academic Press, 2009).
Creed, K. E., Ishikawa, S. & Ito, Y. Electrical and mechanical activity recorded from rabbit urinary bladder in response to nerve stimulation. J. Physiol. 338, 149–164 (1983).
Fujii, K., Foster, C. D., Brading, A. F. & Parekh, A. B. Potassium channel blockers and the effects of cromakalim on the smooth muscle of the guinea-pig bladder. Br. J. Pharmacol. 99, 779–785 (1990).
Hayase, M., Hashitani, H., Kohri, K. & Suzuki, H. Role of K+ channels in regulating spontaneous activity in detrusor smooth muscle in situ in the mouse bladder. J. Urol. 181, 2355–2365 (2009).
Heppner, T. J., Bonev, A. D. & Nelson, M. T. Ca2+-activated K+ channels regulate action potential repolarization in urinary bladder smooth muscle. Am. J. Physiol. 273, C110–C117 (1997).
Nakahira, Y. et al. Effects of isoproterenol on spontaneous excitations in detrusor smooth muscle cells of the guinea pig. J. Urol. 166, 335–340 (2001).
Petkov, G. V., Heppner, T. J., Bonev, A. D., Herrera, G. M. & Nelson, M. T. Low levels of KATP channel activation decrease excitability and contractility of urinary bladder. Am. J. Physiol. Regul. Integr. Comp. Physiol. 280, R1427–R1433 (2001).
Brown, S. M. et al. Beta-adrenergic relaxation of mouse urinary bladder smooth muscle in the absence of large-conductance Ca2+-activated K+ channel. Am. J. Physiol. Renal Physiol. 295, F1149–F1157 (2008).
Chen, M., Kellett, W. F. & Petkov, G. V. Voltage-gated K+ channels sensitive to stromatoxin-1 regulate myogenic and neurogenic contractions of rat urinary bladder smooth muscle. Am. J. Physiol. Regul. Integr. Comp. Physiol. 299, R177–R184 (2010).
Herrera, G. M., Heppner, T. J. & Nelson, M. T. Regulation of urinary bladder smooth muscle contractions by ryanodine receptors and BK and SK channels. Am. J. Physiol. Regul. Integr. Comp. Physiol. 279, R60–R68 (2000).
Herrera, G. M. & Nelson, M. T. Differential regulation of SK and BK channels by Ca2+ signals from Ca2+ channels and ryanodine receptors in guinea-pig urinary bladder myocytes. J. Physiol. 541, 483–492 (2002).
Herrera, G. M. et al. Urinary bladder instability induced by selective suppression of the murine small conductance calcium-activated potassium (SK3) channel. J. Physiol. 551, 893–903 (2003).
Hristov, K. L., Chen, M., Kellett, W. F., Rovner, E. S. & Petkov, G. V. Large conductance voltage- and Ca2+-activated K+ channels regulate human detrusor smooth muscle function. Am. J. Physiol. Cell Physiol. 301, C903–C912 (2011).
Hristov, K. L. et al. Stimulation of β3-adrenoceptors relaxes rat urinary bladder smooth muscle via activation of the large-conductance Ca2+-activated K+ channels. Am. J. Physiol. Cell Physiol. 295, C1344–C1353 (2008).
Petkov, G. V. et al. β1-subunit of the Ca2+-activated K+ channel regulates contractile activity of mouse urinary bladder smooth muscle. J. Physiol. 537, 443–452 (2001).
Hashitani, H. & Brading, A. F. Electrical properties of detrusor smooth muscles from the pig and human urinary bladder. Br. J. Pharmacol. 140, 146–158 (2003).
Imai, T. et al. Effects of different types of K+ channel modulators on the spontaneous myogenic contraction of guinea-pig urinary bladder smooth muscle. Acta Physiol. Scand. 173, 323–333 (2001).
Andersson, K. E. & Wein, A. J. Pharmacology of the lower urinary tract: basis for current and future treatments of urinary incontinence. Pharmacol. Rev. 56, 581–631 (2004).
Baker, S. A. et al. Role of TREK-1 potassium channel in bladder overactivity after partial bladder outlet obstruction in mouse. J. Urol. 183, 793–800 (2010).
Chang, S. et al. Detrusor overactivity is associated with downregulation of large-conductance calcium- and voltage-activated potassium channel protein. Am. J. Physiol. Renal Physiol. 298, F1416–F1423 (2010).
Hristov, K., Afeli, S., Kellett, W. F., Rovner, E. & Petkov, G. V. Neurogenic detrusor overactivity is associated with decreased BK channel activity: electrophysiological and functional studies on human detrusor smooth muscle. J. Urol. 183, e73–e74 (2010).
Jiang, H. H., Song, B., Lu, G. S., Wen, Q. J. & Jin, X. Y. Loss of ryanodine receptor calcium-release channel expression associated with overactive urinary bladder smooth muscle contractions in a detrusor instability model. BJU Int. 96, 428–433 (2005).
Meredith, A. L., Thorneloe, K. S., Werner, M. E., Nelson, M. T. & Aldrich, R. W. Overactive bladder and incontinence in the absence of the BK large conductance Ca2+-activated K+ channel. J. Biol. Chem. 279, 36746–36752 (2004).
Oger, S. et al. Effects of potassium channel modulators on myogenic spontaneous phasic contractile activity in human detrusor from neurogenic patients. BJU Int. 108, 604–611 (2011).
Thorneloe, K. S., Meredith, A. L., Knorn, A. M., Aldrich, R. W. & Nelson, M. T. Urodynamic properties and neurotransmitter dependence of urinary bladder contractility in the BK channel deletion model of overactive bladder. Am. J. Physiol. Renal Physiol. 289, F604–F610 (2005).
Chen, M. & Petkov, G. V. Identification of large conductance calcium activated potassium channel accessory beta4 subunit in rat and mouse bladder smooth muscle. J. Urol. 182, 374–381 (2009).
Hristov, K., Chen, M., Afeli, S., Rovner, E. & Petkov, G. V. Expression and function of voltage-gated K+ channels sensitive to stromatoxin-1 in human detrusor smooth muscle. J. Urol. 185, e91 (2011).
Hristov, K. L. et al. KV2.1 and electrically silent KV channel subunits control excitability and contractility of Guinea pig detrusor smooth muscle. Am. J. Physiol. Cell Physiol. http://dx.doi.org/10.1152/ajpcell.00303.2010.
Hamill, O. P., Marty, A., Neher, E., Sakmann, B. & Sigworth, F. J. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflugers Arch. 391, 85–100 (1981).
Klockner, U. & Isenberg, G. Action potentials and net membrane currents of isolated smooth muscle cells (urinary bladder of the guinea-pig). Pflugers Arch. 405, 329–339 (1985).
Kellett, W. F., Cui, X., Hristov, K. L. & Petkov, G. V. SK and IK Ca2+-activated K+ channels as novel pharmacological targets to control urinary bladder smooth muscle excitability and contractility. FASEB J. 22, 1201–1219 (2008).
Parajuli, S. P., Soder, R. P., Hristov, K. L. & Petkov, G. V. Pharmacological activation of SK channels with SKA-31 decreases Guinea pig detrusor smooth muscle excitability and contractility. J. Pharmacol. Exp. Ther. http://dx.doi.org/10.1124/jpet.111.186213 (2011).
Horn, R. & Marty, A. Muscarinic activation of ionic currents measured by a new whole-cell recording method. J. Gen. Physiol. 92, 145–159 (1988).
Petkov, G. V. & Nelson, M. T. Differential regulation of Ca2+-activated K+ channels by β-adrenoceptors in guinea pig urinary bladder smooth muscle. Am. J. Physiol. Cell Physiol. 288, C1255–C1263 (2005).
Sprossmann, F. et al. Inducible knockout mutagenesis reveals compensatory mechanisms elicited by constitutive BK channel deficiency in overactive murine bladder. FEBS J. 276, 1680–1697 (2009).
Pandita, R. K., Ronn, L. C., Jensen, B. S. & Andersson, K. E. Urodynamic effects of intravesical administration of the new small/intermediate conductance calcium activated potassium channel activator NS309 in freely moving, conscious rats. J. Urol. 176, 1220–1224 (2006).
Streng, T., Christoph, T. & Andersson, K. E. Urodynamic effects of the K+ channel (KCNQ) opener retigabine in freely moving, conscious rats. J. Urol. 172, 2054–2058 (2004).
Thorneloe, K. S. & Nelson, M. T. Properties and molecular basis of the mouse urinary bladder voltage-gated K+ current. J. Physiol. 549, 65–74 (2003).
Gutman, G. A. et al. International Union of Pharmacology. XLI. Compendium of voltage-gated ion channels: potassium channels. Pharmacol. Rev. 55, 583–586 (2003).
Gutman, G. A. et al. International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. Pharmacol. Rev. 57, 473–508 (2005).
Wulff, H., Castle, N. A. & Pardo, L. A. Voltage-gated potassium channels as therapeutic targets. Nat. Rev. Drug Discov. 8, 982–1001 (2009).
Davies, A. M., Batchelor, T. J., Eardley, I. & Beech, D. J. Potassium channel KVα1 subunit expression and function in human detrusor muscle. J. Urol. 167, 1881–1886 (2002).
Ohya, S., Tanaka, M., Watanabe, M. & Maizumi, Y. Diverse expression of delayed rectifier K+ channel subtype transcripts in several types of smooth muscles of the rat. J. Smooth Muscle Res. 36, 101–115 (2000).
Gan, X. G., An, R. H., Bai, Y. F. & Zong, D. B. Expressions of voltage-gated K+ channel 2.1 and 2.2 in rat bladder with detrusor hyperreflexia. Chin. Med. J. (Engl.) 121, 1574–1577 (2008).
Escoubas, P., Diochot, S., Celerier, M. L., Nakajima, T. & Lazdunski, M. Novel tarantula toxins for subtypes of voltage-dependent potassium channels in the Kv2 and Kv4 subfamilies. Mol. Pharmacol. 62, 48–57 (2002).
Moreno-Dominguez, A., Cidad, P., Miguel-Velado, E., Lopez-Lopez, J. R. & Perez-Garcia, M. T. De novo expression of Kv6.3 contributes to changes in vascular smooth muscle cell excitability in a hypertensive mice strain. J. Physiol. 587, 625–640 (2009).
Rode, F., Svalo, J., Sheykhzade, M. & Ronn, L. C. Functional effects of the KCNQ modulators retigabine and XE991 in the rat urinary bladder. Eur. J. Pharmacol. 638, 121–127 (2010).
Herrera, G. M., Heppner, T. J. & Nelson, M. T. Voltage dependence of the coupling of Ca2+ sparks to BKCa channels in urinary bladder smooth muscle. Am. J. Physiol. Cell Physiol. 280, C481–C490 (2001).
Soder, R. P. & Petkov, G. V. Large conductance Ca2+-activated K+ channel activation with NS1619 decreases myogenic and neurogenic contractions of rat detrusor smooth muscle. Eur. J. Pharmacol. 670, 252–259 (2011).
Suarez-Kurtz, G., Garcia, M. L. & Kaczorowski, G. J. Effects of charybdotoxin and iberiotoxin on the spontaneous motility and tonus of different guinea pig smooth muscle tissues. J. Pharmacol. Exp. Ther. 259, 439–443 (1991).
Knaus, H. G. et al. Tremorgenic indole alkaloids potently inhibit smooth muscle high-conductance calcium-activated potassium channels. Biochemistry 33, 5819–5828 (1994).
Layne, J. J., Nausch, B., Olesen, S. P. & Nelson, M. T. BK channel activation by NS11021 decreases excitability and contractility of urinary bladder smooth muscle. Am. J. Physiol. Regul. Integr. Comp. Physiol. 298, R378–R384 (2010).
Siemer, C., Bushfield, M., Newgreen, D. & Grissmer, S. Effects of NS1608 on MaxiK channels in smooth muscle cells from urinary bladder. J. Membr. Biol. 173, 57–66 (2000).
Ohi, Y. et al. Local Ca2+ transients and distribution of BK channels and ryanodine receptors in smooth muscle cells of guinea-pig vas deferens and urinary bladder. J. Physiol. 534, 313–326 (2001).
Kita, M. et al. Effects of bladder outlet obstruction on properties of Ca2+-activated K+ channels in rat bladder. Am. J. Physiol. Regul. Integr. Comp. Physiol. 298, R1310–R1319 (2010).
Hashitani, H. & Brading, A. F. Ionic basis for the regulation of spontaneous excitation in detrusor smooth muscle cells of the guinea-pig urinary bladder. Br. J. Pharmacol. 140, 159–169 (2003).
Darblade, B. et al. Effects of potassium channel modulators on human detrusor smooth muscle myogenic phasic contractile activity: potential therapeutic targets for overactive bladder. Urology 68, 442–448 (2006).
Herrera, G. M., Etherton, B., Nausch, B. & Nelson, M. T. Negative feedback regulation of nerve-mediated contractions by KCa channels in mouse urinary bladder smooth muscle. Am. J. Physiol. Regul. Integr. Comp. Physiol. 289, R402–R409 (2005).
Kellett, W. F. & Petkov, G. V. Role of Ca2+-activated K+ channel in the neurogenic contractions induced by electrical field stimulation in detrusor smooth muscle isolated from rats and guinea pigs. Biophys. J. 98, 125a–126a (2010).
Malysz, J. et al. Functional characterization of large conductance calcium-activated K+ channel openers in bladder and vascular smooth muscle. Naunyn Schmiedebergs Arch. Pharmacol. 369, 481–489 (2004).
Parajuli, S. P., Hristov, K., Pandey, R., Rovner, E. S. & Petkov, G. V. BK channel activation with NS1619 decreases excitability and contractility of human urinary bladder smooth muscle. FASEB J. 25, 1115.14 (2011).
Nelson, M. T. et al. Relaxation of arterial smooth muscle by calcium sparks. Science 270, 633–637 (1995).
Takemoto, J. et al. Potentiation of potassium currents by β-adrenoceptor agonists in human urinary bladder smooth muscle cells: a possible electrical mechanism of relaxation. Pharmacology 81, 251–258 (2008).
Kobayashi, H., Adachi-Akahane, S. & Nagao, T. Involvement of BKCa channels in the relaxation of detrusor muscle via β-adrenoceptors. Eur. J. Pharmacol. 404, 231–238 (2000).
Li, L. et al. Changes in T-type calcium channel and its subtypes in overactive detrusor of the rats with partial bladder outflow obstruction. Neurourol. Urodyn. 26, 870–878 (2007).
Aydin, M., Wang, H.-Z., Melman, A. & DiSanto, M. E. Large conductance calcium-activated potassium channel activity, as determined by whole cell patch clamp recording, is decreased in urinary bladder smooth muscle cells from male rats with partial urethral obstruction. J. Urol. 181 (Suppl.), 542 (2009).
Hotta, S. et al. Ryanodine receptor type 2 deficiency changes excitation-contraction coupling and membrane potential in urinary bladder smooth muscle. J. Physiol. 582, 489–506 (2007).
Davies, K. P. et al. Ageing causes cytoplasmic retention of MaxiK channels in rat corporal smooth muscle cells. Int. J. Impot. Res. 19, 371–377 (2007).
Toro, L. et al. Aging, ion channel expression, and vascular function. Vascul. Pharmacol. 38, 73–80 (2002).
Christ, G. J. et al. Bladder injection of “naked” hSlo/pcDNA3 ameliorates detrusor hyperactivity in obstructed rats in vivo. Am. J. Physiol. Regul. Integr. Comp. Physiol. 281, R1699–R1709 (2001).
Christ, G. J. Potential applications of gene therapy/transfer to the treatment of lower urinary tract diseases/disorders. Handb. Exp. Pharmacol. 202, 255–265 (2011).
Melman, A., Bar-Chama, N., McCullough, A., Davies, K. & Christ, G. Plasmid-based gene transfer for treatment of erectile dysfunction and overactive bladder: results of a phase I trial. Isr. Med. Assoc. J. 9, 143–146 (2007).
Melman, A. & Feder, M. Gene therapy for the treatment of erectile dysfunction. Nat. Clin. Pract. Urol. 5, 60–61 (2008).
Melman, A., Rojas, L. & Christ, G. Gene transfer for erectile dysfunction: will this novel therapy be accepted by urologists? Curr. Opin. Urol. 19, 595–600 (2009).
Maylie, J., Bond, C. T., Herson, P. S., Lee, W. S. & Adelman, J. P. Small conductance Ca2+-activated K+ channels and calmodulin. J. Physiol. 554, 255–261 (2004).
Thorneloe, K. S. et al. Small-conductance, Ca2+-activated K+ channel 2 is the key functional component of SK channels in mouse urinary bladder. Am. J. Physiol. Regul. Integr. Comp. Physiol. 294, R1737–R1743 (2008).
Nielsen, J. S. et al. Effect of the SK/IK channel modulator 4,5-dichloro-1,3-diethyl-1,3-dihydro-benzoimidazol-2-one (NS4591) on contractile force in rat, pig and human detrusor smooth muscle. BJU Int. 108, 771–777 (2011).
Hougaard, C. et al. A positive modulator of KCa2 and KCa3 channels, 4,5-dichloro-1,3-diethyl-1,3-dihydro-benzoimidazol-2-one (NS4591), inhibits bladder afferent firing in vitro and bladder overactivity in vivo. J. Pharmacol. Exp. Ther. 328, 28–39 (2009).
Sankaranarayanan, A. et al. Naphtho[1,2-d]thiazol-2-ylamine (SKA-31), a new activator of KCa2 and KCa3.1 potassium channels, potentiates the endothelium-derived hyperpolarizing factor response and lowers blood pressure. Mol. Pharmacol. 75, 281–295 (2009).
Chen, M. X. et al. Small and intermediate conductance Ca2+-activated K+ channels confer distinctive patterns of distribution in human tissues and differential cellular localisation in the colon and corpus cavernosum. Naunyn Schmiedebergs Arch. Pharmacol. 369, 602–615 (2004).
Ohya, S. et al. SK4 encodes intermediate conductance Ca2+-activated K+ channels in mouse urinary bladder smooth muscle cells. Jpn J. Pharmacol. 84, 97–100 (2000).
Wulff, H. et al. Design of a potent and selective inhibitor of the intermediate-conductance Ca2+-activated K+ channel, IKCa1: a potential immunosuppressant. Proc. Natl Acad. Sci. USA 97, 8151–8156 (2000).
Kajioka, S. et al. Levcromakalim and MgGDP activate small conductance ATP-sensitive K+ channels of K+ channel pore 6.1/sulfonylurea receptor 2A in pig detrusor smooth muscle cells: uncoupling of cAMP signal pathways. J. Pharmacol. Exp. Ther. 327, 114–123 (2008).
Kajioka, S. et al. Diphosphate regulation of adenosine triphosphate sensitive potassium channel in human bladder smooth muscle cells. J. Urol. 186, 736–744 (2011).
Davis-Taber, R. et al. [125I]A-312110, a novel high-affinity 1,4-dihydropyridine ATP-sensitive K+ channel opener: characterization and pharmacology of binding. Mol. Pharmacol. 64, 143–153 (2003).
Shieh, C. C. et al. Functional implication of spare ATP-sensitive K+ channels in bladder smooth muscle cells. J. Pharmacol. Exp. Ther. 296, 669–675 (2001).
Foster, C. D., Fujii, K., Kingdon, J. & Brading, A. F. The effect of cromakalim on the smooth muscle of the guinea-pig urinary bladder. Br. J. Pharmacol. 97, 281–291 (1989).
Heppner, T. J., Bonev, A., Li, J. H., Kau, S. T. & Nelson, M. T. Zeneca ZD6169 activates ATP-sensitive K+ channels in the urinary bladder of the guinea pig. Pharmacology 53, 170–179 (1996).
Andersson, K. E. et al. Effects of pinacidil on bladder muscle. Drugs 36 (Suppl. 7), 41–49 (1988).
Bonev, A. D. & Nelson, M. T. ATP-sensitive potassium channels in smooth muscle cells from guinea pig urinary bladder. Am. J. Physiol. 264, C1190–C1200 (1993).
Sanders, K. M. & Koh, S. D. Two-pore-domain potassium channels in smooth muscles: new components of myogenic regulation. J. Physiol. 570, 37–43 (2006).
Baker, S. A. et al. Methionine and its derivatives increase bladder excitability by inhibiting stretch-dependent K+ channels. Br. J. Pharmacol. 153, 1259–1271 (2008).
Beckett, E. A. et al. Functional and molecular identification of pH-sensitive K+ channels in murine urinary bladder smooth muscle. BJU Int. 102, 113–124 (2008).
Tertyshnikova, S. et al. BL-1249 [(5,6,7,8-tetrahydro-naphthalen-1-yl)-[2-(1H-tetrazol-5-yl)-phenyl]-amine]: a putative potassium channel opener with bladder-relaxant properties. J. Pharmacol. Exp. Ther. 313, 250–259 (2005).
Acknowledgements
The author thanks the members of his research group (Drs J. Malysz, K. Hristov, S. Parajuli, W. Xin, Ms A. Smith, Ms R. Soder, Mr S. Afeli and Mr Q. Cheng), as well as Dr J. Schnellmann for the critical evaluation of the manuscript. This work was supported by grants from the NIH (DK084284 and DK083687).
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Petkov, G. Role of potassium ion channels in detrusor smooth muscle function and dysfunction. Nat Rev Urol 9, 30–40 (2012). https://doi.org/10.1038/nrurol.2011.194
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