Skip to main content

Advertisement

SpringerLink
Log in

Bone research in 2012

The ups and downs of bone in health and rheumatic disease

  • Year in Review
  • Published:

From Nature Reviews Rheumatology

View current issue Sign up to alerts

In 2012, several new concepts emerged that widen our view of the regulation of bone mass in health and disease. Three key studies outline these discoveries, which affect our understanding of the skeletal system, particularly its physiological function and the changes it undergoes during inflammatory disease.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: Osteoimmune crosstalk regulates osteoblast and osteoclast differentiation and activity.

References

  1. Del Fattore, A., Teti, A. & Rucci, N. Bone cells and the mechanisms of bone remodelling. Front. Biosci. (Elite Ed.) 4, 2302–2321 (2012).

    Article  Google Scholar 

  2. Nakahama, K. Cellular communications in bone homeostasis and repair. Cell. Mol. Life Sci. 67, 4001–4009 (2010).

    Article  CAS  Google Scholar 

  3. Luo, Y., Raible, D. & Raper, J. A. Collapsin: a protein in brain that induces the collapse and paralysis of neuronal growth cones. Cell 75, 217–227 (1993).

    Article  CAS  Google Scholar 

  4. Hayashi, M. et al. Osteoprotection by semaphorin 3A. Nature 485, 69–74 (2012).

    Article  CAS  Google Scholar 

  5. Braun, T. & Zwerina, J. Positive regulators of osteoclastogenesis and bone resorption in rheumatoid arthritis. Arthritis Res. Ther. 13, 235 (2011).

    Article  CAS  Google Scholar 

  6. Saeki, Y. et al. Baseline anti-citrullinated peptide antibody (ACPA) titers and serum interleukin-6 (IL-6) levels possibly predict progression of bone destruction in early stages of rheumatoid arthritis (ERA). Rheumatol. Int. http://dx.doi.org/10.1007/s00296-012-239720131.

  7. Harre, U. et al. Induction of osteoclastogenesis and bone loss by human autoantibodies against citrullinated vimentin. J. Clin. Invest. 122, 1791–1802 (2012).

    Article  CAS  Google Scholar 

  8. Sherlock, J. P. et al. IL-23 induces spondyloarthropathy by acting on ROR-γt+ CD3+CD4−CD8− entheseal resident T cells. Nat. Med. 18, 1069–1076 (2012).

    Article  CAS  Google Scholar 

  9. Sieper, J. Developments in therapies for spondyloarthritis. Nat. Rev. Rheumatol. 8, 280–287 (2012).

    Article  CAS  Google Scholar 

Download references

Acknowledgements

The work of Georg Schett is supported by the Deutsche Forschungsgemeinschaft (SPP1468-IMMUNOBONE). Ulrike Harre is a member of Graduiertenkolleg 1660, supported by the Deutsche Forschungsgemeinschaft.

Author information

Authors and Affiliations

  1. Department of Internal Medicine 3, University of Erlangen-Nuremberg, Erlangen, 91054, Germany

    Ulrike Harre & Georg Schett

Authors
  1. Ulrike Harre
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Georg Schett
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Georg Schett.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Harre, U., Schett, G. The ups and downs of bone in health and rheumatic disease. Nat Rev Rheumatol 9, 67–68 (2013). https://doi.org/10.1038/nrrheum.2012.219

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nrrheum.2012.219

  • Springer Nature Limited

Search

Navigation