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Symptom perception in patients with NERD: do nerves matter?

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From Nature Reviews Gastroenterology & Hepatology

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Various mechanisms eliciting symptoms in GERD and its most common phenotypic presentation, nonerosive reflux disease (NERD), have been suspected and investigated. One study now suggests that superficial nerves in the oesophageal epithelium might have a key role in the pathogenesis of NERD and could represent a potential target for topical therapies.

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Authors and Affiliations

  1. Division of Gastroenterology, Department of Surgery, Oncology and Gastroenterology, University of Padua, Via Giustiniani 2, Padua, 35128, Italy

    Edoardo Savarino & Marco della Coletta

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  1. Edoardo Savarino
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  2. Marco della Coletta
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Correspondence to Edoardo Savarino.

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The authors declare no competing financial interests.

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Savarino, E., Coletta, M. Symptom perception in patients with NERD: do nerves matter?. Nat Rev Gastroenterol Hepatol 14, 634–636 (2017). https://doi.org/10.1038/nrgastro.2017.120

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