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Hippocampal theta rhythms follow the beat of their own drum

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The firing of most hippocampal neurons is modulated by the theta rhythm, but it's not clear how and where the rhythm is generated. A study now shows that the required machinery for theta generation lies in local circuits of the hippocampus.

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Figure 1: The upper trace shows theta recorded from the CA1 apical dendrites of a freely moving rat (L.L.C. and E.I.M., unpublished data), whereas the lower trace shows theta waves in the whole-hippocampus preparation of Goutagny et al.4 (their Fig. 1c).

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Authors and Affiliations

  1. Kavli Institute for Systems Neuroscience and Centre for the Biology of Memory, Medical-Technical Research Centre, Norwegian University of Science and Technology, Trondheim, Norway

    Laura Lee Colgin & Edvard I Moser

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  1. Laura Lee Colgin
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  2. Edvard I Moser
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Correspondence to Edvard I Moser.

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Colgin, L., Moser, E. Hippocampal theta rhythms follow the beat of their own drum. Nat Neurosci 12, 1483–1484 (2009). https://doi.org/10.1038/nn1209-1483

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