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High times for memory: cannabis disrupts temporal coordination among hippocampal neurons

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Exogenous cannabinoid receptor agonists impair hippocampus-dependent learning and decrease the power of hippocampal electroencephalographic activity. A new paper shows that cannabinoids desynchronize neuronal assemblies without affecting average firing rates, and that this effect correlates with memory deficits in individuals.

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Figure 1: Cell assemblies and the effect of cannabinoids according to Robbe and colleagues1.

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Authors and Affiliations

  1. Department of Anatomy & Neurobiology, University of California, Irvine, 92697, California, USA

    Ivan Soltesz

  2. Department of Neurology, Massachusetts General Hospital, Boston, 02114, Massachusetts, USA

    Kevin Staley

Authors
  1. Ivan Soltesz
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  2. Kevin Staley
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Soltesz, I., Staley, K. High times for memory: cannabis disrupts temporal coordination among hippocampal neurons. Nat Neurosci 9, 1461–1463 (2006). https://doi.org/10.1038/nn1206-1461

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