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Fresh air is good for nerves: hypoxia disturbs axon guidance

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The transcription factor hypoxia-inducible factor 1 (HIF-1) triggers multiple cellular responses to cope with hypoxia. A study in this issue suggests that elevated HIF-1 also causes axon guidance defects under hypoxic conditions.

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Figure 1: Model for the effects of hypoxia on axon guidance3.

Kim Caesar

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Authors and Affiliations

  1. Helen Wills Neuroscience Institute and the Department of Molecular and Cell Biology, 16 Barker Hall, University of California, Berkeley, 94720-3204, California, USA

    Chun-Liang Pan & Gian Garriga

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  1. Chun-Liang Pan
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  2. Gian Garriga
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Pan, CL., Garriga, G. Fresh air is good for nerves: hypoxia disturbs axon guidance. Nat Neurosci 11, 859–861 (2008). https://doi.org/10.1038/nn0808-859

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