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Out of control in the dendrites

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Although voltage-clamp recordings remain a favorite method for studying synaptic transmission, the space-clamp problems that are associated with somatic voltage-clamp recordings have never been directly measured. A study by Williams and Mitchell in this issue now measures the experimental errors associated with this technique.

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Figure 1: Diagram depicting the poor space clamp of dendritic conductances from the experiments of Williams and Mitchell2.

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Authors and Affiliations

  1. Nelson Spruston is in the Department of Neurobiology & Physiology, Northwestern University, 2205 Tech Dr., Evanston, 60208, Illinois, USA

    Nelson Spruston

  2. Daniel Johnston is at the Center for Learning and Memory, University of Texas at Austin, 2506 Speedway, Austin, 78705, Texas, USA

    Daniel Johnston

Authors
  1. Nelson Spruston
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  2. Daniel Johnston
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Spruston, N., Johnston, D. Out of control in the dendrites. Nat Neurosci 11, 733–734 (2008). https://doi.org/10.1038/nn0708-733

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