Abstract
The dendritic surface area of a neuron may be 10, 20, or even 100 times greater than the surface area of the neuron soma. This dendritic membrane provides a large distributed capacity that is electrically coupled to the soma by various cable distances along the branched core conductor. When a voltage clamp is applied across the soma membrane, the dendritic membrane is neither space clamped nor voltage clamped, except for the special case of very short dendritic trees.
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References
Araki, T., and C. A. Terzuolo. Membrane currents in spinal motoneurones associated with the action potential and synaptic activity. J. Neurophysiol. 25: 772–789, 1962.
Barrett, J. N., and W. E. Crill. Specific membrane properties of cat motoneurones. J. Physiol. London 239: 301–324, 1974.
Barrett, J. N., and W. E. Crill. Influences of dendritic location and membrane properties on the effectiveness of synapses on cat motoneurones. J. Physiol. London 239: 325345, 1974.
Barrett, J. N., and W. E. Crill. Voltage clamp of cat motoneurone somata: properties of the fast inward current. J. Physiol. London 304: 231–249, 1980.
Brown, T. H., and D. Johnston. Voltage-clamp analysis of mossy fiber synaptic input to hippocampal neurons. J. Neurophysiol. 50: 487–507, 1983.
Butz, E. G., and J. D. Cowan. Transient potentials in dendritic systems of arbitrary geometry. Biophys. J. 14: 661–689, 1974.
Calvin, W. H. Dendritic synapses and reversal potentials: theoretical implications of the view from the soma. Exp. Neural. 24: 248–264, 1969.
Carnevale, N. T., and D. Johnston. Electrophysiological characterization of remote chemical synapses. J. Neurophysiol. 47: 606–621, 1982.
Carslaw, H. S., and J. C. Jaeger. Conduction of Heat in Solids. London: Oxford Univ. Press, 1959.
Finkel, A. S., and S. J. Redman. The synaptic current evoked in cat spinal motoneurones by impulses in single group Ia axons. J. Physiol. London 342: 615–632, 1983.
Frank, K., M. G. F. Fuortes, and P. G. Nelson. Voltage clamp of motoneuron soma. Science 130: 38–39, 1959.
Horwitz, B. An analytical method for investigating transient potentials in neurons with branching dendritic trees. Biophys. J. 36: 155–192, 1981.
Horwitz, B. Unequal diameters and their effects on time varying voltages in branched neurons. Biophys. J. 41: 51–66, 1983.
Jack, J. J. B., D. Noble, and R. W. Tsien. Electric Current Flow in Excitable Cells. London: Oxford Univ. Press, 1975.
Jack, J. J. B., and S. J. Redman. An electrical description of the motoneurone and its application to the analysis of synaptic potentials. J. Physiol. London 215: 321–352, 1971.
Johnston, D., and T. H. Brown. Interpretation of voltage-clamp measurements in hippocampal neurons. J. Neurophysiol. 50: 464–486, 1983.
Joyner, R. W., J. W. Moore, and F. Ramon. Axon voltage-clamp simulations. III. Postsynaptic region. Biophys. J. 15: 37–54, 1975.
Perkel, D. H., and B. Mulloney. Electrotonic properties of neurons: steady state compartmental model. J. Neurophysiol. 41: 621–639, 1978.
Rall, W. Branching dendritic trees and motoneuron membrane resistivity. Exp. Neurol. 1: 491–527, 1959.
Rall, W. Membrane potential transients and membrane time constant of motoneurons. Exp. Neurol. 2: 503–532, 1960.
Rall, W. Theory of physiological properties of dendrites. Ann. NYAcad. Sci. 96: 1071 1092, 1962.
Rall, W. Theoretical significance of dendritic trees for neuronal input-output relations. In: Neural Theory and Modeling, edited by R. Reiss. Stanford, CA: Stanford Univ. Press, 1964, p. 73–97.
Rall, W. Distinguishing theoretical synaptic potentials computed for different somadendritic distributions of synaptic input. J. Neurophysiol. 30: 1138–1168, 1967.
Rall, W. Time constants and electrotonic length of membrane cylinders and neurons. Biophys. J. 9: 1483–1508, 1969.
Rall, W. Core conductor theory and cable properties of neurons. In: Handbook of Physiology. The Nervous System. Cellular Biology of Neurons, edited by J. M. Brookhart and V. B. Mountcastle. Bethesda, MD: Am. Physiol. Soc., 1977, vol. 1, pt. 1, chapt. 3, p. 39–97.
Rall, W., R. E. Burke, T. G. Smith, P. G. Nelson, and K. Frank. Dendritic location of synapses and possible mechanisms for the monosynaptic EPSP in motoneurons. J. Neurophysiol. 30: 1169–1193, 1967.
Rall, W., and J. Rinzel. Branch input resistance and steady attenuation for input to one branch of a dendritic neuron model. Biophys. J. 13: 648–688, 1973.
Redman, S. J. The attenuation of passively propagating dendritic potentials in a motoneurone cable model. J. Physiol. London 234: 637–664, 1973.
Rinzel, J., and W. Rall. Transient response in a dendritic neuron model for current injected at one branch. Biophys. J. 14: 759–790, 1974.
Selverston, A. I., D. F. Russell, J. P. Miller, and D. G. King. The stomatogastric nervous system: structure and function of a small neural network. Prog. Neurobiol. 7: 215–290, 1976.
Turner, D. A., and P. A. Schwartzkroin. Steady-state electrotonic analysis of intracellularly stained hippocampal neurons. J. Neurophysiol. 44: 184–199, 1980.
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© 1985 American Physiological Society
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Rall, W., Segev, I. (1985). Space-Clamp Problems When Voltage Clamping Branched Neurons With Intracellular Microelectrodes. In: Smith, T.G., Lecar, H., Redman, S.J., Gage, P.W. (eds) Voltage and Patch Clamping with Microelectrodes. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7601-6_9
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DOI: https://doi.org/10.1007/978-1-4614-7601-6_9
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