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Life and death rest on a bivalent chromatin state

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Neurons require lifelong maintenance of their transcriptional program, which includes stable expression of cell-type-specific identity genes. A study now shows that PRC2-mediated chromatin repression in adulthood is critical for the maintenance of neuronal identity gene expression and neuronal survival.

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Figure 1: The PRC2 complex includes histone H3K27 methyltransferase Ezh1 or Ezh2, along with several other protein subunits3.

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Authors and Affiliations

  1. Department of Psychiatry & Biobehavioral Sciences, X. William Yang is at the Center for Neurobehavioral Genetics, Semel Institute for Human Behavior, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, USA.,

    X William Yang

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  1. X William Yang
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Correspondence to X William Yang.

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Yang, X. Life and death rest on a bivalent chromatin state. Nat Neurosci 19, 1271–1273 (2016). https://doi.org/10.1038/nn.4396

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