Sub-microsecond, downhill-reaction protein folding can be investigated by a method to generate large and fast pressure drops. The approach is complementary to nanosecond temperature-jump methods and could provide new insights into the biophysics of protein folding.
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References
Gruebele, M. Annu. Rev. Phys. Chem. 50, 485–516 (1999).
Dumont, C., Emilsson, T. & Gruebele, M. Nat. Methods 6, 515–519 (2009).
Sadqi, M., Lapidus, L.J. & Muñoz, V. Proc. Natl. Acad. Sci. USA 100, 12117–12122 (2003).
Eaton, W.A. et al. Annu. Rev. Biophys. Biomol. Struct. 29, 327–359 (2000).
Kubelka, J., Hofrichter, J. & Eaton, W.A. Curr. Opin. Struct. Biol. 14, 76–88 (2004).
Muñoz, V. Annu. Rev. Biophys. Biomol. Struct. 36, 395–412 (2007).
Snow, C.D., Sorin, E.J., Rhee, Y.M. & Pande, V.S. Annu. Rev. Biophys. Biomol. Struct. 34, 43–69 (2005).
Yang, W.Y. & Gruebele, M. Nature 423, 193–197 (2003).
Sadqi, M., Fushman, D. & Muñoz, V. Nature 442, 317–321 (2006).
Royer, C.A. Arch. Biochem. Biophys. 469, 35–45 (2008).
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Muñoz, V. Downhill protein folding under pressure. Nat Methods 6, 490–491 (2009). https://doi.org/10.1038/nmeth0709-490
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DOI: https://doi.org/10.1038/nmeth0709-490
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