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siRNA delivery

Loaded-up microsponges

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Self-assembled microsponges of hairpin RNA polymers achieve, with one thousand times lower concentration, the same degree of gene silencing in tumour-carrying mice as conventional nanoparticle-based siRNA delivery vehicles.

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Figure 1: Schematic outlining the one-pot synthesis of polymers of short double-stranded RNA (dsRNA) hairpins and their spontaneous assembly, over approximately 20 h, into 2-μm-diameter RNAi microsponges through a series of intermediate structures1.
Figure 2: Complementary strategies to generate multifunctional RNA nanoparticles.

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Authors and Affiliations

  1. Department of Chemistry and Biochemistry, University of California, Santa Barbara, 93106-9510, California, USA

    Wade W. Grabow & Luc Jaeger

  2. Biomolecular Science and Engineering Program, University of California, Santa Barbara, 93106-9510, California, USA

    Luc Jaeger

Authors
  1. Wade W. Grabow
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  2. Luc Jaeger
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Correspondence to Luc Jaeger.

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Grabow, W., Jaeger, L. Loaded-up microsponges. Nature Mater 11, 268–269 (2012). https://doi.org/10.1038/nmat3286

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