A demonstration of inhibition of β-sheets in both reactive amyloid, using an in vivo mouse model, and synthetic Alzheimer (β) amyloid, in vitro (pages 143–148).
References
Kisilevsky, R. et al. Arresting amyloidosis in vivo using small-molecule anionic sulphonates or sulphates. Nature Medicine 1, 143–148 (1995).
Benson, M.D. in Metabolic Basis of Inherited Disease, (eds. Scriver, C.R., Beaudet, A.L., Sly, W.S. & Valle, D.,) 7th edn., 4159–4191 (McGraw Hill, New York, 1994).
McKusick, V.A. Mendelian Inheritance in Man (Johns Hopkins Univ. Press, Baltimore, 1992).
Ghiso, J., Wisniewski, T. & Frangione, B. Unifying features in systematic and cerebral amyloidosis. Mol. Neurobiol. 8, 49–64 (1994).
Mullan, M.J. et al. A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of β-amyloid. Nature Genet. 1, 345–347 (1992).
Schellenbert G.D. et al. Genetic linkage evidence for a familial Alzhaimer's Disease Locus on Chromosome 14. Science 258, 668–671 (1992).
Corder, E.H. et al. Gene Dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science 261, 921–923 (1993).
Okuizumi, K. et al. ApoE-ε4 and early-onset Alzheimer's. Nature Genet. 7, 10–11 (1994).
Roses, A.D. Apoliprotein E affects the rate of Alzheimer's diease expression: β-amyloid burden is a secondary consequence dependant on apo E genotypes and duration of disease. J. Neuropathol. Exp. Neurol. 53, 429–437 (1994).
Tsuda, T. et al. Are the associations between Alzheimer's disease and polymorphisms in the apolipoprotein E and the apolipoprotein CII gene due to linkage disequilibrium? Ann. Neurol. 36, 97–100 (1994).
Leveugle, B. et al. Binding of heparin sulphate gly-cosaminoglycan to β-amyloid peptide: inhibition by potentially therapeutic polysulphated compounds. NeuroReport 5, 1389–1392 (1994).
Caubhey, B. Scrapie-associated PrP acculmulation and agent replication: Effects of sulphated gly-cosaminoglycan analogues. Philosoph. Trans. R. Soc. Land. B. Biol. Sci. 343, 399–404 (1994).
Maness, L.M. et al. Passage of human amyloid β-protein 1-40 across the murine blood-brain barrier. Life Sci. 55, 1643–1650 (1994).
Duff, K.J. Modelling Alzheimer's disase in transgenic mice. Fla. Med. Assoc. 91, 625–628 (1994).
Price, D.L. & Sisodia, S.S. Cellular and molecular biology of Alzheimer's diease animal model. Annu. Rev. Med. 45, 435–446 (1994).
Higgins, L.S. et al. Transgenic mouse brain histopathology resembles early Alzheimer's diease. Ann. Neurol. 35, 598–607 (1994).
Snow, A.D. et al. An important role for heparin sul-fate proteoglycan (Perlecan) in a model system for the deposition and persistence of fibrillar A beta-amyloid in rat brain. Neuron 12, 219–234 (1994).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Diehl, S. Sand in the sheets. Nat Med 1, 120–122 (1995). https://doi.org/10.1038/nm0295-120
Issue Date:
DOI: https://doi.org/10.1038/nm0295-120
- Springer Nature America, Inc.