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AIDS virus seeks refuge in B cell follicles

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A study of SIV-infected rhesus macaques suggests that T follicular helper (TFH) cells, a specialized CD4+ T cell subset within the B cell follicles, are a sanctuary for SIV that is largely inaccessible to CD8+ T cells. These findings may open new avenues for research aimed at eradicating HIV.

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Figure 1: Fukazawa et al.3 find that in ECs SIV is located in a specialized CD4+ T cell subset, TFH cells, in B cell follicles of the lymph nodes.

Marina Corral Spence/Nature Publishing Group

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Acknowledgements

H.S. is funded by a cooperative agreement (W81XWH-07-2-0067) between the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., and the US Department of Defense (DOD). The views expressed are those of the author and should not be construed to represent the positions of the US Army or the Department of Defense.

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  1. Hendrik Streeck is in the US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA, and at the Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA.,

    Hendrik Streeck

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  1. Hendrik Streeck
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Correspondence to Hendrik Streeck.

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Streeck, H. AIDS virus seeks refuge in B cell follicles. Nat Med 21, 111–112 (2015). https://doi.org/10.1038/nm.3795

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