A new study demonstrates involvement of the inhibitory receptor CTLA-4 in T cell exhaustion during infection with human immunodeficiency virus, adding complexity and diversity to the inhibitory pathways regulating T cell responses during chronic viral infections in humans.
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Crawford, A., Wherry, E. Inhibitory receptors: whose side are they on?. Nat Immunol 8, 1201–1203 (2007). https://doi.org/10.1038/ni1107-1201
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DOI: https://doi.org/10.1038/ni1107-1201
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