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Oxidative burst without phagocytes: the role of respiratory proteins

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Respiratory proteins of vertebrates (hemoglobin) and invertebrates (hemocyanin) can generate highly reactive oxygen intermediates. New work shows that microbial compounds directly activate this release of reactive oxygen intermediates that kills the microbes.

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Figure 1: The generation of ROIs in vertebrates (mammals) versus invertebrates (arthropods).

Kim Caesar

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Authors and Affiliations

  1. Christian Bogdan, Institute of Clinical Microbiology, Immunology and Hygiene, University Clinic of Erlangen, D-91054 Erlangen, Germany. christian.bogdan@uk-erlangen.de,

    Christian Bogdan

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  1. Christian Bogdan
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The author declares no competing financial interests.

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Bogdan, C. Oxidative burst without phagocytes: the role of respiratory proteins. Nat Immunol 8, 1029–1031 (2007). https://doi.org/10.1038/ni1007-1029

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