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Nonsynonymous variants and fatty liver disease

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Fat accumulation in the liver is a common trait that may progress to severe liver disease. A new study identifies common and rare nonsynonymous variants in PNPLA3 that are associated with hepatic triglyceride content and that may explain some of the population differences in prevalence.

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Figure 1: Liver histology of an individual with nonalcoholic fatty liver disease14.

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Authors and Affiliations

  1. Karen L. Mohlke is in the Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27516, USA. mohlke@med.unc.edu,

    Karen L Mohlke

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  1. Karen L Mohlke
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Mohlke, K. Nonsynonymous variants and fatty liver disease. Nat Genet 40, 1394–1395 (2008). https://doi.org/10.1038/ng1208-1394

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