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Motheaten and viable motheaten mice have mutations in the haematopoietic cell phosphatase gene

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Abstract

Mice with the recessive motheaten (me) or the allelic viable motheaten (mev) mutations express a severe autoimmune and immunodeficiency syndrome. We have shown that the basic defect in these mice involves lesions in the gene which encodes haematopoietic cell phosphatase (HCP). These mice thus provide excellent models for investigating the roles of phosphatases in haematopoiesis and the nature of the genetic and cellular events linking impaired haematopoiesis to severe immunodeficiency and expression of systemic autoimmunity.

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Authors and Affiliations

  1. Western Division, The Toronto Hospital, Mc14–417, 399 Bathurst Street, Toronto, Ontario, M5T2S8, Canada

    Hing Wo Tsui, Loretta de Souza & Florence W.L. Tsui

  2. Departments of Medicine and Immunology, University of Toronto,

    Katherine A. Siminovitch & Florence W.L. Tsui

  3. the Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada

    Katherine A. Siminovitch & Florence W.L. Tsui

  4. Molecular and Medical Genetics, University of Toronto,

    Katherine A. Siminovitch

  5. the Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada

    Katherine A. Siminovitch

Authors
  1. Hing Wo Tsui
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  2. Katherine A. Siminovitch
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  3. Loretta de Souza
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  4. Florence W.L. Tsui
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Wo Tsui, H., Siminovitch, K., de Souza, L. et al. Motheaten and viable motheaten mice have mutations in the haematopoietic cell phosphatase gene. Nat Genet 4, 124–129 (1993). https://doi.org/10.1038/ng0693-124

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  • DOI: https://doi.org/10.1038/ng0693-124

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