Skip to main content
SpringerLink
Log in

Is a super-enhancer greater than the sum of its parts?

  • Correspondence
  • Published:

From Nature Genetics

View current issue Submit your manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: Generalized linear models applied to published knockout data for the α-globin and Wap super-enhancers.

References

  1. Hay, D. et al. Nat. Genet. 48, 895–903 (2016).

    Article  CAS  Google Scholar 

  2. Shin, H.Y. et al. Nat. Genet. 48, 904–911 (2016).

    Article  CAS  Google Scholar 

  3. Hnisz, D. et al. Cell 155, 934–947 (2013).

    Article  CAS  Google Scholar 

  4. Whyte, W.A. et al. Cell 153, 307–319 (2013).

    Article  CAS  Google Scholar 

  5. Heinz, S., Romanoski, C.E., Benner, C. & Glass, C.K. Nat. Rev. Mol. Cell Biol. 16, 144–154 (2015).

    Article  CAS  Google Scholar 

  6. Pott, S. & Lieb, J.D. Nat. Genet. 47, 8–12 (2015).

    Article  CAS  Google Scholar 

  7. Nelder, J.A. & Wedderburn, R.W.M. J. R. Stat. Soc. [Ser A] 135, 370–384 (1972).

    Article  Google Scholar 

  8. Lässig, M. BMC Bioinformatics 8 (Suppl. 6), S7 (2007).

    Article  Google Scholar 

  9. Phillips, R. Annu. Rev. Condens. Matter Phys. 6, 85–111 (2015).

    Article  CAS  Google Scholar 

  10. Crocker, J., Ilsley, G.R. & Stern, D.L. Nat. Genet. 48, 292–298 (2016).

    Article  CAS  Google Scholar 

Download references

Acknowledgements

We thank the authors of refs. 1 and 2 for providing their raw data. We thank B. Cohen, C. Danko and J. Lis for comments on the manuscript and J. Kinney for useful discussions about biophysical models. This research was supported in part by US National Institutes of Health grants GM102192 and HG007070. The content is solely the responsibility of the authors and does not necessarily represent the official views of the US National Institutes of Health.

Author information

Author notes

  1. Noah Dukler, Brad Gulko and Yi-Fei Huang: These authors contributed equally to this work.

Authors and Affiliations

  1. Simons Center for Quantitative Biology, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA

    Noah Dukler, Brad Gulko, Yi-Fei Huang & Adam Siepel

  2. Graduate Field of Computer Science, Cornell University, Ithaca, New York, USA

    Brad Gulko

Authors
  1. Noah Dukler
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Brad Gulko
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Yi-Fei Huang
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Adam Siepel
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Adam Siepel.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Supplementary information

Supplementary Figures and Texts

Supplementary Figures 1–7, Supplementary Tables 1–4 and Supplementary Note (PDF 641 kb)

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Dukler, N., Gulko, B., Huang, YF. et al. Is a super-enhancer greater than the sum of its parts?. Nat Genet 49, 2–3 (2017). https://doi.org/10.1038/ng.3759

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ng.3759

  • Springer Nature America, Inc.

This article is cited by

Search

Navigation