Skip to main content

Advertisement

SpringerLink
Log in

Is Src the key to understanding metastasis and developing new treatments for colon cancer?

  • Viewpoint
  • Published:

From Nature Clinical Practice Gastroenterology & Hepatology

View current issue Sign up to alerts

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. National Cancer Institute [http://www.seer.cancer.gov/statfacts/html/colorect.html]

  2. Kopetz S et al. (2007) SRC continues aging: current and future clinical directions. Clin Cancer Res 13: 7232–7236

    Article  CAS  Google Scholar 

  3. Nam JS et al. (2002) Src family kinase inhibitor PP2 restores the E-cadherin/catenin cell adhesion system in human cancer cells and reduces cancer metastasis. Clin Cancer Res 8: 2430–2436

    CAS  PubMed  Google Scholar 

  4. Thamilselvan V et al. (2004) Colon cancer cell adhesion in response to Src kinase activation and actin-cytoskeleton by non-laminar shear stress. J Cell Biochem 92: 361–371

    Article  CAS  Google Scholar 

  5. Irby RB et al. (1999) Activating SRC mutation in a subset of advanced human colon cancers. Nat Genet 21: 187–190.

    Article  CAS  Google Scholar 

  6. Zhu S et al. (2007) PTP1B contributes to the oncogenic properties of colon cancer cells through Src activation. Cancer Res 67: 10129–10137

    Article  CAS  Google Scholar 

  7. Thamilselvan V et al. (2007) FAK association with multiple signal proteins mediates pressure-induced colon cancer cell adhesion via a Src-dependent PI3K/Akt pathway. FASEB J 21: 1730–1741

    Article  CAS  Google Scholar 

  8. Avizienyte E et al. (2007) An active Src kinase-beta-actin association is linked to actin dynamics at the periphery of colon cancer cells. Exp Cell Res 313: 3175–3188

    Article  CAS  Google Scholar 

  9. Etienne-Manneville S and Hall A (2002) Rho GTPases in cell biology. Nature 420: 629–635

    Article  CAS  Google Scholar 

  10. Avizienyte E and Frame MC (2005) Src and FAK signalling controls adhesion fate and the epithelial-to-mesenchymal transition. Curr Opin Cell Biol 17: 542–547

    Article  CAS  Google Scholar 

  11. Busa R et al. (2007) The RNA-binding protein Sam68 contributes to proliferation and survival of human prostate cancer cells. Oncogene 26: 4372–4382

    Article  CAS  Google Scholar 

  12. Mamidipudi V et al. (2004) RACK1 regulates G1/S progression by suppressing Src kinase activity. Mol Cell Biol 24: 6788–6798

    Article  CAS  Google Scholar 

Download references

Author information

Author notes

  1. Cancer Biology Program, Diamantina Institute for Cancer, Immunology and Metabolic Medicine, University of Queensland, Princess Alexandra Hospital, Ipswich Road, Brisbane, Qld 4102, Australia j.chen4@uq.edu.au

Authors and Affiliations

  1. J Chen is a Research Officer at the Diamantina Institute for Cancer, Immunology and Metabolic Medicine, University of Queensland, Brisbane, Qld, Australia.,

    Jiezhong Chen

Authors
  1. Jiezhong Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Chen, J. Is Src the key to understanding metastasis and developing new treatments for colon cancer?. Nat Rev Gastroenterol Hepatol 5, 306–307 (2008). https://doi.org/10.1038/ncpgasthep1141

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ncpgasthep1141

  • Springer Nature Limited

This article is cited by

Search

Navigation