Nitric oxide signaling requires that the heme of soluble guanylate cyclase bind NO preferentially to O2. Engineering of the enzyme's active site reveals a molecular basis for NO binding selectivity.
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Spiro, T. Pulling NO out of thin air. Nat Chem Biol 1, 6–7 (2005). https://doi.org/10.1038/nchembio0605-6
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DOI: https://doi.org/10.1038/nchembio0605-6
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