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Protein folding

When ribosomes pick the structure

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Anfinsen's principle tells us that the folded structure of a protein is determined solely by its sequence. Now, it has been shown that the rate at which a polypeptide chain is synthesized in the cell can affect which of two alternative folded structures it adopts.

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Figure 1: Protein folding scenarios described by Clark and co-workers4 for polypeptide YKB.

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Authors and Affiliations

  1. Elin M. Sivertsson and Laura S. Itzhaki are in the Department of Pharmacology at the University of Cambridge, Tennis Court Road, Cambridge, CB2 1PD, UK,

    Elin M. Sivertsson & Laura S. Itzhaki

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  1. Elin M. Sivertsson
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  2. Laura S. Itzhaki
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Correspondence to Laura S. Itzhaki.

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Sivertsson, E., Itzhaki, L. When ribosomes pick the structure. Nature Chem 6, 378–379 (2014). https://doi.org/10.1038/nchem.1926

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