Synthetic receptors with properties resembling those of carbohydrate-binding proteins are known, but they are structurally rather complex. Elaborate structures are, however, not always required to bind carbohydrates in water — much simpler compounds can be just as effective.
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References
Ke, C., Destecroix, H., Crump, M. P. & Davis, A. P. Nature Chem. 4, 718–723 (2012).
James, T. D. & Shinkai, S. Top. Curr. Chem. 218, 159–200 (2002).
Davis, A. P. Org. Biomol. Chem. 7, 3629–3638 (2009).
Klein, E., Crump, M. P. & Davis, A. P. Angew. Chem. Int. Ed. 44, 298–302 (2005).
Ferrand, Y. et al. Angew. Chem. Int. Ed. 48, 1775–1779 (2009).
Ferrand, Y., Crump, M. P. & Davis, A. P. Science 318, 619–622 (2007).
Barwell, N. P., Crump, M. P. & Davis, A. P. Angew. Chem. Int. Ed. 48, 7673–7676 (2009).
Harata, K., Nagahora, H. & Jigami, Y. Acta Cryst. D51, 1013–1019 (1995).
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Kubik, S. A minimalistic approach to binding. Nature Chem 4, 697–698 (2012). https://doi.org/10.1038/nchem.1428
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DOI: https://doi.org/10.1038/nchem.1428
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