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The persistent dynamic secrets of senescence

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While the beneficial versus detrimental implications of the senescence-associated secretome remain an issue of debate, time-resolved analyses of its composition, regulatory mechanisms and functional consequences have been largely missing. The dynamic activity of NOTCH is now shown to direct two distinct senescence phenotypes, by first promoting a pro-senescent TGF-β1-dependent secretome, followed by a second wave of pro-inflammatory, senescence-clearing cytokines.

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Figure 1: A NOTCH1–C/EBPβ-controlled two-wave senescence secretome phenotype.

References

  1. Coppe, J. P., Desprez, P. Y., Krtolica, A. & Campisi, J. Annu. Rev. Pathol. 5, 99–118 (2010).

    Article  CAS  Google Scholar 

  2. Munoz-Espin, D. & Serrano, M. Nat. Rev. Mol. Cell Biol. 15, 482–496 (2014).

    Article  CAS  Google Scholar 

  3. Sagiv, A. & Krizhanovsky, V. Biogerontology 14, 617–628 (2013).

    Article  CAS  Google Scholar 

  4. Hoare, M. et al. Nat. Cell Biol. 18, 979–992 (2016).

    Article  CAS  Google Scholar 

  5. Venkatesh, D. et al. Arterioscler. Thromb. Vasc. Biol. 31, 876–882 (2011).

    Article  CAS  Google Scholar 

  6. Krizhanovsky, V. et al. Cell 134, 657–667 (2008).

    Article  CAS  Google Scholar 

  7. Weng, A. P. et al. Science 306, 269–271 (2004).

    Article  CAS  Google Scholar 

  8. Acosta, J. C. et al. Nat. Cell Biol. 15, 978–990 (2013).

    Article  CAS  Google Scholar 

  9. Kuilman, T. et al. Cell 133, 1019–1031 (2008).

    Article  CAS  Google Scholar 

  10. Bash, J. et al. EMBO J. 18, 2803–2811 (1999).

    Article  CAS  Google Scholar 

  11. Schwarzer, R., Dorken, B. & Jundt, F. Leukemia 26, 806–813 (2012).

    Article  CAS  Google Scholar 

  12. Macosko, E. Z. et al. Cell 161, 1202–1214 (2015).

    Article  CAS  Google Scholar 

  13. Baker, D. J. et al. Nature 479, 232–236 (2011).

    Article  CAS  Google Scholar 

  14. Dörr, J. R. et al. Nature 501, 421–425 (2013).

    Article  Google Scholar 

  15. Reimann, M. et al. Cancer Cell 17, 262–272 (2010).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Medical Department, Division of Hematology, Clemens A. Schmitt is at Charité–Universitätsmedizin Berlin, Oncology and Tumor Immunology, and the Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Augustenburger Platz 1, 13353 Berlin, Germany,

    Clemens A. Schmitt

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  1. Clemens A. Schmitt
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Correspondence to Clemens A. Schmitt.

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Schmitt, C. The persistent dynamic secrets of senescence. Nat Cell Biol 18, 913–915 (2016). https://doi.org/10.1038/ncb3403

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