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miR-29b moulds the tumour microenvironment to repress metastasis

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Tumour cells are influenced by their microenvironment, which can promote uncontrolled growth, invasion and metastasis. The GATA3 transcription factor is now shown to regulate the tumour microenvironment by inducing the expression of miR-29b in cancer cells. This microRNA in turn inhibits the expression of genes involved in angiogenesis and extracellular matrix signalling and remodelling to suppress metastasis.

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Figure 1: A signalling network comprising GATA3, TGF-β and miR-29b contributes to the control of metastasis.

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Authors and Affiliations

  1. Sonia A. Melo and Raghu Kalluri are in the Department of Cancer Biology, Metastasis Research Center, University of Texas MD Anderson Cancer Center, Houston 77054, Texas, USA,

    Sonia A. Melo & Raghu Kalluri

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  1. Sonia A. Melo
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  2. Raghu Kalluri
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Correspondence to Raghu Kalluri.

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The authors declare no competing financial interests.

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Melo, S., Kalluri, R. miR-29b moulds the tumour microenvironment to repress metastasis. Nat Cell Biol 15, 139–140 (2013). https://doi.org/10.1038/ncb2684

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