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A sugar switch for anti-inflammatory antibodies

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The finding that antibody sialylation can suppress inflammation provides new opportunities for drug development.

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Figure 1: The IgG molecule comprises two light (L) and two heavy (H) chains in covalent and noncovalent association to generate three independent protein moieties: two antigen-binding (Fab) regions and the crystallizable fragment (Fc), responsible for effector functions such as cell killing and counteracting inflammation, are connected thorough a flexible linker, the hinge region.

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  1. Division of Immunity and Infection, The Medical School, University of Birmingham, Vincent Drive, Edgbaston, Birmingham, UK

    Roy Jefferis

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  1. Roy Jefferis
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Jefferis, R. A sugar switch for anti-inflammatory antibodies. Nat Biotechnol 24, 1230–1231 (2006). https://doi.org/10.1038/nbt1006-1230

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