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Systematic phenotyping of mouse mutants

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Comprehensive phenotypic screening of knockout mice highlights the pleiotropic functions of secreted and transmembrane proteins.

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Figure 1: The comprehensive screen performed by Tang et al.1 scored phenotypes of mice, each of which had one of 472 genes encoding membrane and secreted proteins knocked out, to reveal the involvement of the deleted gene in the function of different organ systems.

References

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Authors and Affiliations

  1. Wolfgang Wurst and Martin Hrabe de Angelis are at the Helmholtz Zentrum München, Munich/Neuherberg, Germany.,

    Wolfgang Wurst & Martin Hrabe de Angelis

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  1. Wolfgang Wurst
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  2. Martin Hrabe de Angelis
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Correspondence to Wolfgang Wurst or Martin Hrabe de Angelis.

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The authors declare no competing financial interests.

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Wurst, W., de Angelis, M. Systematic phenotyping of mouse mutants. Nat Biotechnol 28, 684–685 (2010). https://doi.org/10.1038/nbt0710-684

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