Skip to main content
SpringerLink
Log in

A microbial factory for diverse chemicals

  • News & Views
  • Published:

From Nature Biotechnology

View current issue Submit your manuscript

An array of functionalized small molecules is efficiently synthesized in bacteria.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: Cheong et al.1 generate a large array of functionalized small molecules by feeding the reverse β-oxidation cycle with primer and extender molecules that contain diverse functional groups (R1 and R2) and using different termination pathways.

References

  1. Cheong, S., Clomburg, J. & Gonzalez, R. Nat. Biotechnol. 34, 556–561 (2016).

    Article  CAS  Google Scholar 

  2. Dellomonaco, C., Clomburg, J.M., Miller, E.N. & Gonzalez, R. Nature 476, 355–359 (2011).

    Article  CAS  Google Scholar 

  3. Zhang, K., Sawaya, M.R., Eisenberg, D.S. & Liao, J.C. Proc. Natl. Acad. Sci. USA 105, 20653–20658 (2008).

    Article  CAS  Google Scholar 

  4. Clomburg, J.M., et al. Metab. Eng. 28, 202–212 (2015).

    Article  CAS  Google Scholar 

  5. Torella, J.P. et al. Proc. Natl. Acad. Sci. USA 110, 11290–11295 (2013).

    Article  CAS  Google Scholar 

  6. Felnagle, E.A., Chaubey, A., Noey, E.L., Houk, K.N. & Liao, J.C. Nat. Chem. Biol. 8, 518–526 (2012).

    Article  CAS  Google Scholar 

  7. Van Dien, S. Curr. Opin. Biotechnol. 24, 1061–1068 (2013).

    Article  CAS  Google Scholar 

  8. Tai, Y.S., et al. Nat. Chem. Biol. 12, 247–253 (2016).

    Article  CAS  Google Scholar 

  9. Chowdhury, A. & Maranas, C.D. Sci. Rep. 5, 16009 (2015).

    Article  CAS  Google Scholar 

  10. Zhang, F., Carothers, J.M. & Keasling, J.D. Nat. Biotechnol. 30, 354–359 (2012).

    Article  CAS  Google Scholar 

  11. Xiao, Y., Bowen, C.H., Liu, D. & Zhang, F. Nat. Chem. Biol. 12, 339–344 (2016).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Anupam Chowdhury & Costas D. Maranas are at the Department of Chemical Engineering, Chiam Yu Ng, The Pennsylvania State University, University Park, Pennsylvania, USA.,

    Chiam Yu Ng, Anupam Chowdhury & Costas D Maranas

Authors
  1. Chiam Yu Ng
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Anupam Chowdhury
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Costas D Maranas
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Costas D Maranas.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Ng, C., Chowdhury, A. & Maranas, C. A microbial factory for diverse chemicals. Nat Biotechnol 34, 513–515 (2016). https://doi.org/10.1038/nbt.3565

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nbt.3565

  • Springer Nature America, Inc.

Search

Navigation