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Neurodegeneration

Aggregates feel the strain

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Aggregates of α-synuclein protein can form in various cell types and cause different neurodegenerative disorders. The existence of strains with distinct structural conformations might explain this variability. See Letter p.340

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Figure 1: Structural variability and disease.

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Authors and Affiliations

  1. Department of Medicine, Seung-Jae Lee is at the Neuroscience Research Institute, Seoul National University College of Medicine, Seoul 110-799, Korea.,

    Seung-Jae Lee

  2. Eliezer Masliah is in the Department of Pathology and Neurosciences, University of California, San Diego, La Jolla, California 92093, USA.,

    Eliezer Masliah

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  1. Seung-Jae Lee
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  2. Eliezer Masliah
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Correspondence to Seung-Jae Lee or Eliezer Masliah.

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Lee, SJ., Masliah, E. Aggregates feel the strain. Nature 522, 296–297 (2015). https://doi.org/10.1038/nature14526

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