Skip to main content
SpringerLink
Log in

Cancer

Damage prevention targeted

  • News & Views
  • Published:

From Nature

View current issue Submit your manuscript

The MTH1 protein prevents oxidized nucleotides from being misincorporated into DNA. Two studies find that selective inhibition of MTH1 by small molecules suppresses tumour growth. See Articles p.215 & p.222

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: Role of the MTH1 protein.

References

  1. Cairns, R. A., Harris, I. S. & Mak, T. W. Nature Rev. Cancer 11, 85–95 (2011).

    Article  CAS  Google Scholar 

  2. Luo, M., He, H., Kelley, M. R. & Georgiadis, M. M. Antioxid. Redox Signal. 12, 1247–1269 (2010).

    Article  CAS  Google Scholar 

  3. Yoshimura, D. et al. J. Biol. Chem. 278, 37965–37973 (2003).

    Article  CAS  Google Scholar 

  4. Gad, H. et al. Nature 508, 215–221 (2014).

    Article  ADS  CAS  Google Scholar 

  5. Huber, K. V. M. et al. Nature 508, 222–226 (2014).

    Article  ADS  CAS  Google Scholar 

  6. Tsuzuki, T., Egashira, A. & Kura, S. Mutat. Res. 477, 71–78 (2001).

    Article  CAS  Google Scholar 

  7. Topal, M. D. & Baker, M. S. Proc. Natl Acad. Sci. USA 79, 2211–2215 (1982).

    Article  ADS  CAS  Google Scholar 

  8. Fujikawa, K. et al. J. Biol. Chem. 274, 18201–18205 (1999).

    Article  CAS  Google Scholar 

  9. Toyokuni, S., Okamoto, K., Yodoi, J. & Hiai, H. FEBS Lett. 358, 1–3 (1995).

    Article  CAS  Google Scholar 

  10. Zhang, Y. et al. Antioxid. Redox Signal. 15, 2867–2908 (2011).

    Article  CAS  Google Scholar 

  11. Rai, P. et al. Oncogene 30, 1489–1496 (2011).

    Article  CAS  Google Scholar 

  12. Russo, M. T. et al. Mol. Cell. Biol. 24, 465–474 (2004).

    Article  CAS  Google Scholar 

  13. Kumar, C. C. et al. Cancer Res. 55, 5106–5117 (1995).

    CAS  PubMed  Google Scholar 

  14. Camidge, D. R. et al. Lancet Oncol. 13, 1011–1019 (2012).

    Article  CAS  Google Scholar 

  15. Fujikawa, K., Kamiya, H., Yakushiji, H., Nakabeppu, Y. & Kasai, H. Nucleic Acids Res. 29, 449–454 (2001).

    Article  CAS  Google Scholar 

  16. Bestwick, R. K., Moffett, G. L. & Mathews, C. K. J. Biol. Chem. 257, 9300–9304 (1982).

    CAS  PubMed  Google Scholar 

  17. Tanaka, M., Chock, P. B. & Stadtman, E. R. Proc. Natl Acad. Sci. USA 104, 66–71 (2007).

    Article  ADS  CAS  Google Scholar 

  18. Nunomura, A. et al. Neurotox. Res. 22, 231–248 (2012).

    Article  CAS  Google Scholar 

  19. Trachootham, D., Alexandre, J. & Huang, P. Nature Rev. Drug Discov. 8, 579–591 (2009).

    Article  CAS  Google Scholar 

  20. Raj, L. et al. Nature 475, 231–234 (2011).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Dan Dominissini and Chuan He are in the Department of Chemistry and Institute for Biophysical Dynamics, and at the Howard Hughes Medical Institute, University of Chicago, Chicago, Illinois 60637, USA.,

    Dan Dominissini & Chuan He

Authors
  1. Dan Dominissini
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Chuan He
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Dan Dominissini or Chuan He.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Dominissini, D., He, C. Damage prevention targeted. Nature 508, 191–192 (2014). https://doi.org/10.1038/nature13221

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nature13221

  • Springer Nature Limited

Search

Navigation