Skip to main content
SpringerLink
Log in

Cell biology

Receptor signals come in waves

  • News & Views
  • Published:

From Nature

View current issue Submit your manuscript

The activity of G-protein-coupled receptors is not limited to the cell surface. Evidence from microscopy points to three temporally, spatially and perhaps functionally distinct waves of signalling by these receptors. See Letter p.534

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: One receptor, three signals.

Notes

  1. *This article and the paper under discussion4 were published online on 20 March 2013.

References

  1. Harmsen, M. M. & De Haard, H. J. Appl. Microbiol. Biotechnol. 77, 13–22 (2007).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Hamers-Casterman, C. et al. Nature 363, 446–448 (1993).

    Article  ADS  CAS  PubMed  Google Scholar 

  3. Steyaert, J. & Kobilka, B. K. Curr. Opin. Struct. Biol. 21, 567–572 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Irannejad, R. et al. Nature 495, 534–538 (2013).

    Article  ADS  CAS  PubMed  Google Scholar 

  5. Lohse, M. J., Benovic, J. L., Codina, J., Caron, M. G. & Lefkowitz, R. J. Science 248, 1547–1550 (1990).

    Article  ADS  CAS  PubMed  Google Scholar 

  6. Shenoy, S. K. & Lefkowitz, R. J. Trends Pharmacol. Sci. 32, 521–533 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Calebiro, D., Nikolaev, V. O., Persani, L. & Lohse, M. J. Trends Pharmacol. Sci. 31, 221–228 (2010).

    Article  CAS  PubMed  Google Scholar 

  8. Ferrandon, S. et al. Nature Chem. Biol. 5, 734–742 (2009).

    Article  CAS  Google Scholar 

  9. Calebiro, D. et al. PLoS Biol. 7, e1000172 (2009).

    Article  PubMed  PubMed Central  Google Scholar 

  10. Mullershausen, F. et al. Nature Chem. Biol. 5, 428–434 (2009).

    Article  CAS  Google Scholar 

  11. Kotowski, S. J., Hopf, F. W., Seif, T., Bonci, A. & von Zastrow, M. Neuron 71, 278–290 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Feinstein, T. N. et al. Nature Chem. Biol. 7, 278–284 (2011).

    Article  CAS  Google Scholar 

  13. Werthmann, R. et al. FASEB J. 26, 2043–2048 (2012).

    Article  CAS  PubMed  Google Scholar 

  14. Zürn, A. et al. Mol. Pharmacol. 75, 534–541 (2009).

    Article  PubMed  Google Scholar 

  15. Nygaard, R. et al. Cell 152, 532–542 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Martin J. Lohse and Davide Calebiro are at the Institute of Pharmacology and Toxicology, and the Rudolf Virchow Center, University of Würzburg, 97078 Würzburg, Germany.,

    Martin J. Lohse & Davide Calebiro

Authors
  1. Martin J. Lohse
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Davide Calebiro
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lohse, M., Calebiro, D. Receptor signals come in waves. Nature 495, 457–458 (2013). https://doi.org/10.1038/nature12086

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nature12086

  • Springer Nature Limited

This article is cited by

Search

Navigation