The activity of G-protein-coupled receptors is not limited to the cell surface. Evidence from microscopy points to three temporally, spatially and perhaps functionally distinct waves of signalling by these receptors. See Letter p.534
Notes
*This article and the paper under discussion4 were published online on 20 March 2013.
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Lohse, M., Calebiro, D. Receptor signals come in waves. Nature 495, 457–458 (2013). https://doi.org/10.1038/nature12086
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DOI: https://doi.org/10.1038/nature12086
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