Malfunction of presenilin enzymes, which cleave proteins in cell membranes, can lead to Alzheimer's disease. A crystal structure of a microbial presenilin provides insights into the workings of this enzyme family. See Article p.56
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*This article and the paper under discussion4 were published online on 19 December 2012.
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Wolfe, M. Membrane enzyme cuts a fine figure. Nature 493, 34–35 (2013). https://doi.org/10.1038/nature11768
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DOI: https://doi.org/10.1038/nature11768
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