Developing therapeutic drugs that target peptide receptors is challenging. The structure of one of these G-protein-coupled receptors, NTS1, activated and bound to a peptide, provides an excellent starting point. See Article p.508
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*This article and the paper under discussion2 were published online on 10 October 2012.
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Hausch, F., Holsboer, F. Snapshot of an activated peptide receptor. Nature 490, 492–493 (2012). https://doi.org/10.1038/nature11634
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DOI: https://doi.org/10.1038/nature11634
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