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Neutral evolution of ‘non-coding’ complementary DNAs (reply)

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Abstract

Wang et al.1 challenge our suggestion that almost half of the 33,407 representative putative full-length cDNAs identified by RIKEN are probably non-coding RNAs2. The challenge is based on bioinformatic analyses showing that the level of conservation of these sequences is no greater than that observed for intergenic sequences, and less than that observed in a control set of documented ncRNAs.

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Authors and Affiliations

  1. Laboratory for Genome Exploration Research Group, RIKEN Genomic Science Center, RIKEN Yokohama Institute, Suehiro-cho, Tsurumi-ku, Yokohama, 230-0045, Kanagawa, Japan

    Yoshihide Hyashizaki

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  1. Yoshihide Hyashizaki
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Correspondence to Yoshihide Hyashizaki.

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Hyashizaki, Y. Neutral evolution of ‘non-coding’ complementary DNAs (reply). Nature 431, 2–3 (2004). https://doi.org/10.1038/nature03017

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