Skip to main content

Advertisement

SpringerLink
Log in

Lenalidomide-mediated erythroid improvement in non-del(5q) myelodysplastic syndromes is associated with bone marrow immuno-remodeling

  • Letter to the Editor
  • Published:
Leukemia Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1
Figure 2

References

  1. List A, Dewald G, Bennett J, Giagounidis A, Raza A, Feldman E et al. Lenalidomide in the myelodysplastic syndrome with chromosome 5q deletion. N Engl J Med 2006; 355: 1456–1465.

    Article  CAS  PubMed  Google Scholar 

  2. Fenaux P, Giagounidis A, Selleslag D, Beyne-Rauzy O, Mufti G, Mittelman M et al. A randomized phase 3 study of lenalidomide versus placebo in RBC transfusion-dependent patients with low-/intermediate-1-risk myelodysplastic syndromes with del5q. Blood 2011; 118: 3765–3776.

    Article  CAS  PubMed  Google Scholar 

  3. Santini V, Almeida A, Giagounidis A, Gröpper S, Jonasova A, Vey N et al. Randomized phase III study of lenalidomide versus placebo in RBC transfusion-dependent patients with lower-risk non-del(5q) myelodysplastic syndromes and ineligible for or refractory to erythropoiesis-stimulating agents. J Clin Oncol 2016; 34: 2988–2996.

    Article  CAS  PubMed  Google Scholar 

  4. Komrokji RS, Lancet JE, Swern AS, Chen N, Paleveda J, Lush R et al. Combined treatment with lenalidomide and epoetinalfa in lower-risk patients with myelodysplastic syndrome. Blood 2012; 120: 3419–3424.

    Article  CAS  PubMed  Google Scholar 

  5. Toma A, Kosmider O, Chevret S, Delaunay J, Stamatoullas A, Rose C et al. Lenalidomide with or without erythropoietin in transfusion-dependent erythropoiesis-stimulating agent-refractory lower-risk MDS without 5q deletion. Leukemia 2016; 30: 897–905.

    Article  CAS  PubMed  Google Scholar 

  6. Ebert BL, Galili N, Tamayo P, Bosco J, Mak R, Pretz J et al. An erythroid differentiation signature predicts response to lenalidomide in myelodysplastic syndrome. PLoS Med 2008; 5: e35.

    Article  PubMed  PubMed Central  Google Scholar 

  7. Chesnais V, Renneville A, Toma A, Lambert J, Passet M, Dumont F et al. Effect of lenalidomide treatment on clonal architecture of myelodysplastic syndromes without 5q deletion. Blood 2016; 127: 749–760.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Krönke J, Fink EC, Hollenbach PW, MacBeth KJ, Hurst SN, Udeshi ND et al. Lenalidomide induces ubiquitination and degradation of CK1α in del(5q) MDS. Nature 2015; 523: 183–188.

    Article  PubMed  PubMed Central  Google Scholar 

  9. Basiorka AA, McGraw KL, De Ceuninck L, Griner LN, Zhang L, Clark JA et al. Lenalidomide stabilizes the erythropoietin receptor by inhibiting the E3 ubiquitin ligase RNF41. Cancer Res 2016; 76: 3531–3540.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. McDaniel JM, Zou JX, Fulp W, Chen DT, List AF, Epling-Burnette PK . Reversal of T-cell tolerance in myelodysplastic syndrome through lenalidomide immune modulation. Leukemia 2012; 26: 1425–1429.

    Article  CAS  PubMed  Google Scholar 

  11. Hsu AK, Quach H, Tai T, Prince HM, Harrison SJ, Trapani JA et al. The immunostimulatory effect of lenalidomide on NK-cell function is profoundly inhibited by concurrent dexamethasone therapy. Blood 2011; 117: 1605–1613.

    Article  CAS  PubMed  Google Scholar 

  12. Becht E, Giraldo NA, Lacroix L, Buttard B, Elarouci N, Petitprez F et al. Estimating the population abundance of tissue-infiltrating immune and stromal cell populations using gene expression. Genome Biol 2016; 17: 218.

    Article  PubMed  PubMed Central  Google Scholar 

  13. Linton PJ, Dorshkind K . Age-related changes in lymphocyte development and function. Nat Immunol 2004; 5: 133–139.

    Article  CAS  PubMed  Google Scholar 

  14. Sternberg A, Killick S, Littlewood T, Hatton C, Peniket A, Seidl T et al. Evidence for reduced B-cell progenitors in early (low-risk) myelodysplastic syndrome. Blood 2005; 106: 2982–2991.

    Article  CAS  PubMed  Google Scholar 

  15. Aggarwal S, van de Loosdrecht AA, Alhan C, Ossenkoppele GJ, Westers TM, Bontkes HJ . Role of immune responses in the pathogenesis of low-risk MDS and high-risk MDS: implications for immunotherapy. Br J Haematol 2011; 153: 568–581.

    Article  CAS  PubMed  Google Scholar 

  16. Sloand EM, Mainwaring L, Fuhrer M, Ramkissoon S, Risitano AM, Keyvanafar K et al. Preferential suppression of trisomy 8 compared with normal hematopoietic cell growth by autologous lymphocytes in patients with trisomy 8 myelodysplastic syndrome. Blood 2005; 106: 841–851.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Kiladjian JJ, Bourgeois E, Lobe I, Braun T, Visentin G, Bourhis JH et al. Cytolytic function and survival of natural killer cells are severely altered in myelodysplastic syndromes. Leukemia 2006; 20: 463–470.

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgements

We thank A Renneville, C Preudhomme (Lille), O Wagner-Ballon (Créteil) and E Solary (Villejuif) for helpful discussion, S Baulande from ICGex NGS platform of the Institut Curie and investigators of the Groupe Francophone des Myélodysplasies. This study received a research grant from Celgene and was conducted by two teams labeled by the SIRIC Cancer Research for PErsonalized Medicine CARPEM. OK received a CARPEM fellowship grant.

Author information

Author notes

  1. G Kerdivel, V Chesnais and E Becht: These authors contributed equally to this work.

Authors and Affiliations

  1. Department Development, Institut Cochin, Reproduction, Cancer, Paris, France

    G Kerdivel, V Chesnais, F Dumont, N Chapuis, V Boeva, M Fontenay & O Kosmider

  2. Institut National de la Santé et de la recherche médicale INSERM U1016, Paris, France

    G Kerdivel, V Chesnais, F Dumont, N Chapuis, V Boeva, M Fontenay & O Kosmider

  3. Centre National de la recherche scientifique CNRS UMR8104, Paris, France

    G Kerdivel, V Chesnais, F Dumont, N Chapuis, V Boeva, M Fontenay & O Kosmider

  4. Université Paris Descartes, Paris, France

    G Kerdivel, V Chesnais, E Becht, F Dumont, N Chapuis, V Boeva, W H Fridman, M Fontenay & O Kosmider

  5. Team Computational (Epi-)Genetics of Cancer, Paris, France,

    G Kerdivel & V Boeva

  6. Team Normal and pathological hematopoiesis labeled Ligue nationale contre le cancer, Paris, France,

    V Chesnais, N Chapuis, M Fontenay & O Kosmider

  7. INSERM UMR_S1138, Cancer, Immune controls and Escape, Cordeliers Research Center, Paris, France

    E Becht & W H Fridman

  8. Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore

    E Becht

  9. Assistance Publique-Hôpitaux de Paris, Service d’hématologie clinique et Thérapie Cellulaire, Hôpital Henri-Mondor, Créteil, France

    A Toma

  10. Plateforme Paris Descartes de Bioinformatique, Université Paris Descartes, Paris, France

    N Cagnard

  11. Plateforme de Génomique, Institut Cochin, Paris, France

    F Dumont

  12. Assistance Publique-Hôpitaux de Paris, Service d’hématologie biologique, Hôpital Cochin, Paris, France

    A Rousseau, N Chapuis, M Fontenay & O Kosmider

  13. Assistance Publique-Hôpitaux de Paris, Service d’hématologie senior, Hôpital Saint-Louis, Paris, France

    P Fenaux

  14. Assistance Publique-Hôpitaux de Paris, Laboratoire de Biostatistiques et Epidémiologie clinique INSERM UMR-S 717, Hôpital Saint-Louis, Paris, France

    S Chevret

Authors
  1. G Kerdivel
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. V Chesnais
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. E Becht
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. A Toma
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. N Cagnard
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. F Dumont
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. A Rousseau
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. P Fenaux
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. S Chevret
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. N Chapuis
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. V Boeva
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. W H Fridman
    View author publications

    You can also search for this author in PubMed Google Scholar

  13. M Fontenay
    View author publications

    You can also search for this author in PubMed Google Scholar

  14. O Kosmider
    View author publications

    You can also search for this author in PubMed Google Scholar

Consortia

on behalf of the Groupe Francophone des Myélodysplasies

Corresponding author

Correspondence to M Fontenay.

Ethics declarations

Competing interests

The authors declare no conflict of interest.

Additional information

Supplementary Information accompanies this paper on the Leukemia website

Supplementary information

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Kerdivel, G., Chesnais, V., Becht, E. et al. Lenalidomide-mediated erythroid improvement in non-del(5q) myelodysplastic syndromes is associated with bone marrow immuno-remodeling. Leukemia 32, 558–562 (2018). https://doi.org/10.1038/leu.2017.305

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/leu.2017.305

  • Springer Nature Limited

This article is cited by

Search

Navigation