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Ikaros transcripts Ik6/10 and levels of full-length transcript are critical for chronic myeloid leukaemia blast crisis transformation

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References

  1. Papathanasiou P, Attema JL, Karsunky H, Hosen N, Sontani Y, Hoyne GF et al. Self-renewal of the long-term reconstituting subset of hematopoietic stem cells is regulated by Ikaros. Stem Cell 2009; 27: 3082–3092.

    Article  CAS  Google Scholar 

  2. Francis OL, Payne JL, Su RJ, Payne KJ . Regulator of myeloid differentiation and function: the secret life of Ikaros. World J Biol Chem 2011; 2: 119–125.

    Article  Google Scholar 

  3. Mullighan CG, Goorha S, Radtke I, Miller CB, Coustan-Smith E, Dalton JD et al. Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia. Nature 2007; 446: 758–764.

    Article  CAS  Google Scholar 

  4. Mullighan CG, Miller CB, Radtke I, Phillips LA, Dalton J, Ma J et al. BCR-ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros. Nature 2008; 453: 110–114.

    Article  CAS  Google Scholar 

  5. Iacobucci I, Storlazzi CT, Cilloni D, Lonetti A, Ottaviani E, Soverini S et al. Identification and molecular characterization of recurrent genomic deletions on 7p12 in the IKZF1 gene in a large cohort of BCR-ABL1-positive acute lymphoblastic leukemia patients: on behalf of Gruppo Italiano Malattie Ematologiche dell'Adulto Acute Leukemia Working Party (GIMEMA AL WP). Blood 2009; 114: 2159–2167.

    Article  CAS  Google Scholar 

  6. Mullighan CG, Su X, Zhang J, Radtke I, Phillips LA, Miller CB et al. Deletion of IKZF1 and prognosis in acute lymphoblastic leukemia. N Engl J Med 2009; 360: 470–480.

    Article  CAS  Google Scholar 

  7. Yagi T, Hibi S, Takanashi M, Kano G, Tabata Y, Imamura T et al. High frequency of Ikaros isoform 6 expression in acute myelomonocytic and monocytic leukemias: implications for up-regulation of the antiapoptotic protein Bcl-XL in leukemogenesis. Blood 2002; 99: 1350–1355.

    Article  CAS  Google Scholar 

  8. Jäger R, Gisslinger H, Passamonti F, Rumi E, Berg T, Gisslinger B et al. Deletions of the transcription factor Ikaros in myeloproliferative neoplasms. Leukemia 2010; 24: 1290–1298.

    Article  Google Scholar 

  9. Francis S, Lucas C, Lane S, Wang L, Watmough S, Knight K et al. A population study showing that the advent of second generation tyrosine kinase inhibitors has improved progression-free survival in chronic myeloid leukaemia. Leuk Res 2013; 37: 752–758.

    Article  CAS  Google Scholar 

  10. Calabretta B, Perrotti D . The biology of CML blast crisis. Blood 2004; 103: 4010–4022.

    Article  CAS  Google Scholar 

  11. Grossmann V, Kohlmann A, Zenger M, Schindela S, Eder C, Weissmann S et al. A deep-sequencing study of chronic myeloid leukemia patients in blast crisis (BC-CML) detects mutations in 76.9% of cases. Leukemia 2011; 25: 557–560.

    Article  CAS  Google Scholar 

  12. Cazzaniga G, van Delft FW, Lo Nigro L, Ford AM, Score J, Iacobucci I et al. Twin IKZF1 paper Developmental origins and impact of BCR-ABL1 fusion and IKZF1 deletions in monozygotic twins with Ph+ acute lymphoblastic leukemia. Blood 2011; 118: 5559–5564.

    Article  CAS  Google Scholar 

  13. Joha S, Dauphin V, Leprêtre F, Corm S, Nicolini FE, Roumier C et al. Genomic characterization of Imatinib resistance in CD34+ cell populations from chronic myeloid leukaemia patients. Leuk Res 2011; 35: 448–458.

    Article  CAS  Google Scholar 

  14. Eiring AM, Harb JG, Neviani P, Garton C, Oaks JJ, Spizzo R et al. miR-328 functions as an RNA decoy to modulate hnRNP E2 regulation of mRNA translation in leukemic blasts. Cell 2010; 140: 652–665.

    Article  CAS  Google Scholar 

  15. Lu J, Getz G, Miska EA, Alvarez-Saavedra E, Lamb J, Peck D et al. MicroRNA expression profiles classify human cancers. Nature 2005; 435: 834–838.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Haematology, Royal Liverpool University Hospital, Liverpool, UK

    L Wang

  2. Department of Molecular and Cancer Medicine, Section of Haematology, University of Liverpool, Liverpool, UK

    L Wang, A Howarth & R E Clark

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  1. L Wang
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  2. A Howarth
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  3. R E Clark
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Correspondence to R E Clark.

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Wang, L., Howarth, A. & Clark, R. Ikaros transcripts Ik6/10 and levels of full-length transcript are critical for chronic myeloid leukaemia blast crisis transformation. Leukemia 28, 1745–1747 (2014). https://doi.org/10.1038/leu.2014.99

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