Skip to main content
Log in

Impact of serum storage conditions on microRNA stability

  • Letter to the Editor
  • Published:
Leukemia Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Figure 1

References

  1. Scholer N, Langer C, Dohner H, Buske C, Kuchenbauer F . Serum microRNAs as a novel class of biomarkers: a comprehensive review of the literature. Exp Hematol 2010; 38: 1126–1130.

    Article  Google Scholar 

  2. Scholer N, Langer C, Kuchenbauer F . Circulating microRNAs as biomarkers—true blood? Genome Med 2011; 3: 72.

    Article  Google Scholar 

  3. Mitchell PS, Parkin RK, Kroh EM, Fritz BR, Wyman SK, Pogosova-Agadjanyan EL et al. Circulating microRNAs as stable blood-based markers for cancer detection. Proc Natl Acad Sci USA 2008; 105: 10513–10518.

    Article  CAS  Google Scholar 

  4. Arroyo JD, Chevillet JR, Kroh EM, Ruf IK, Pritchard CC, Gibson DF et al. Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma. Proc Natl Acad Sci USA 2011; 108: 5003–5008.

    Article  CAS  Google Scholar 

  5. Petriv OI, Kuchenbauer F, Delaney AD, Lecault V, White A, Kent D et al. Comprehensive microRNA expression profiling of the hematopoietic hierarchy. Proc Natl Acad Sci USA 2010; 107: 15443–15448.

    Article  CAS  Google Scholar 

  6. Kuchenbauer F, Mah SM, Heuser M, McPherson A, Ruschmann J, Rouhi A et al. Comprehensive analysis of mammalian miRNA* species and their role in myeloid cells. Blood 2011; 118: 3350–3358.

    Article  CAS  Google Scholar 

  7. Song J, Bai Z, Han W, Zhang J, Meng H, Bi J et al. Identification of suitable reference genes for qPCR analysis of serum microRNA in gastric cancer patients. Dig Dis Sci 2012; 57: 897–904.

    Article  CAS  Google Scholar 

  8. Kopreski MS, Benko FA, Kwak LW, Gocke CD . Detection of tumor messenger RNA in the serum of patients with malignant melanoma. Clin Cancer Res 1999; 5: 1961–1965.

    CAS  PubMed  Google Scholar 

  9. Tsui NB, Ng EK, Lo YM . Stability of endogenous and added RNA in blood specimens, serum, and plasma. Clin Chem 2002; 48: 1647–1653.

    CAS  PubMed  Google Scholar 

Download references

Acknowledgements

This study was supported by the Deutsche Krebshilfe grant (109420), the European Hematology Association fellowship (2010/04) and by the Deutsche Forschungsgemeinschaft grant (KU2288/3-1).

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Florian Kuchenbauer.

Ethics declarations

Competing interests

The authors declare no conflict of interest.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Grasedieck, S., Schöler, N., Bommer, M. et al. Impact of serum storage conditions on microRNA stability. Leukemia 26, 2414–2416 (2012). https://doi.org/10.1038/leu.2012.106

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/leu.2012.106

  • Springer Nature Limited

This article is cited by

Navigation