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MicroRNA signatures characterize multiple myeloma patients

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References

  1. Gutiérrez NC, Sarasquete ME, Misiewicz-Krzeminska I, Delgado M, De Las Rivas J, Ticona FV et al. Deregulation of microRNA expression in the different genetic subtypes of multiple myeloma and correlation with gene expression profiling. Leukemia 2010; 24: 629–637.

    Article  Google Scholar 

  2. Lionetti M, Biasiolo M, Agnelli L, Todoerti K, Mosca L, Fabris S et al. Identification of microRNA expression patterns and definition of a microRNA/mRNA regulatory network in distinct molecular groups of multiple myeloma. Blood 2009; 114: e20–e26.

    Article  CAS  Google Scholar 

  3. Pichiorri F, Suh SS, Ladetto M, Kuehl M, Palumbo T, Drandi D et al. MicroRNAs regulate critical genes associated with multiple myeloma pathogenesis. Proc Natl Acad Sci USA 2008; 105: 12885–12890.

    Article  CAS  Google Scholar 

  4. O’Donnell KA, Wentzel EA, Zeller KI, Dang CV, Mendell JT . c-Myc-regulated microRNAs modulate E2F1 expression. Nature 2005; 435: 839–843.

    Article  Google Scholar 

  5. Benjamini Y, Hochberg Y . Controlling the false discovery rate: a powerful apporach to multiple testing. J Roy Statist Soc Ser B (Methodological) 1995; 57: 289–300.

    Google Scholar 

  6. Pichiorri F, Suh SS, Rocci A, De Luca L, Taccioli C, Santhanam R et al. Downregulation of p53-inducible microRNAs 192, 194, and 215 impairs the p53/MDM2 autoregulatory loop in multiple myeloma development. Cancer Cell 2010; 18: 367–381.

    Article  CAS  Google Scholar 

  7. Asangani IA, Rasheed SA, Nikolova DA, Leupold JH, Colburn NH, Post S et al. MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer. Oncogene 2008; 27: 2128–2136.

    Article  CAS  Google Scholar 

  8. Loffler D, Brocke-Heidrich K, Pfeifer G, Stocsits C, Hackermuller J, Kretzschmar AK et al. Interleukin-6 dependent survival of multiple myeloma cells involves the Stat3-mediated induction of microRNA-21 through a highly conserved enhancer. Blood 2007; 110: 1330–1333.

    Article  Google Scholar 

  9. Oh J, Takahashi R, Kondo S, Mizoguchi A, Adachi E, Sasahara RM et al. The membrane-anchored MMP inhibitor RECK is a key regulator of extracellular matrix integrity and angiogenesis. Cell 2001; 107: 789–800.

    Article  CAS  Google Scholar 

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Acknowledgements

We thank JF van Galen and MM Wattel from the Erasmus Medical Center for performing additional FISH analysis.

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Correspondence to P Sonneveld.

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Competing interests

Professor Dr P Sonneveld has served on advisory boards of Johnson & Johnson and Millennium Pharmaceuticals.

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Supplementary Information accompanies the paper on the Leukemia website

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Corthals, S., Sun, S., Kuiper, R. et al. MicroRNA signatures characterize multiple myeloma patients. Leukemia 25, 1784–1789 (2011). https://doi.org/10.1038/leu.2011.147

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