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A pilot study of continuous imatinib vs pulsed imatinib with or without G-CSF in CML patients who have achieved a complete cytogenetic response

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References

  1. Druker BJ, Guilhot F, O'Brien SG, Gathmann I, Kantarjian H, Gattermann N et al. Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia. N Engl J Med 2006; 355: 2408–2417.

    CAS  Google Scholar 

  2. Graham SM, Jorgensen HG, Allan E, Pearson C, Alcorn MJ, Richmond L et al. Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to STI571 in vitro. Blood 2002; 99: 319–325.

    Article  CAS  Google Scholar 

  3. Rousselot P, Huguet F, Rea D, Legros L, Cayuela JM, Maarek O et al. Imatinib mesylate discontinuation in patients with chronic myelogenous leukemia in complete molecular remission for more than 2 years. Blood 2007; 109: 58–60.

    Article  CAS  Google Scholar 

  4. Marin D, Kaeda J, Szydlo R, Saunders S, Fleming A, Howard J et al. Monitoring patients in complete cytogenetic remission after treatment of CML in chronic phase with imatinib: patterns of residual leukaemia and prognostic factors for cytogenetic relapse. Leukemia 2005; 19: 507–512.

    Article  CAS  Google Scholar 

  5. Jorgensen HG, Copland M, Allan EK, Jiang X, Eaves A, Eaves C et al. Intermittent exposure of primitive quiescent chronic myeloid leukemia cells to granulocyte-colony stimulating factor in vitro promotes their elimination by imatinib mesylate. Clin Cancer Res 2006; 12: 626–633.

    Article  CAS  Google Scholar 

  6. Khorashad JS, Anand M, Marin D, Saunders S, Al-Jabary T, Iqbal A et al. The presence of a BCR-ABL mutant allele in CML does not always explain clinical resistance to imatinib. Leukemia 2006; 20: 658–663.

    Article  CAS  Google Scholar 

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Acknowledgements

This research was supported by the Leukaemia Research Fund CTAP (UK), Chugai Pharmaceutical Co. Ltd, Chugai Pharma, France and Novartis Pharmaceuticals (UK). We are grateful to Lindsay Mitchell and Karen Stewart for their help with recruitment and assessment of patients. We thank the ‘Délégation à la recherche clinique des Hospices Civils de Lyon’ for their support in setting up this trial in France and Elodie Gadolet, CRA, for her help in collecting the data for the French patients. Drs Steve O'Brien, Heather Jorgensen and Alex McMahon assisted in reviewing the data.

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Drummond, M., Heaney, N., Kaeda, J. et al. A pilot study of continuous imatinib vs pulsed imatinib with or without G-CSF in CML patients who have achieved a complete cytogenetic response. Leukemia 23, 1199–1201 (2009). https://doi.org/10.1038/leu.2009.43

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